Recruiting

TES-TI

Sponsor:

University of Wisconsin, Madison

Code:

NCT07752745

Conditions

Transcranial Electric Stimulation

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Interventions

TES-TI with hdEEG

Study Details

Brief summary:

This study is to find out whether and how a type of non-invasive electrical brain stimulation called transcranial electrical stimulation with temporal interference (TES-TI) can temporarily change brain activity in healthy adults. A structural MRI scan will be used to customize where the stimulation electrodes are placed for each participant to deliver TES-TI during three afternoon sessions at rest with eyes closed. Brain activity is recorded with high-density EEG. Up to 24 participants will be enrolled and on study for 3 to 12 weeks.

Conditions

Transcranial Electric Stimulation

Study ID

NCT07752745

Start date

Sep, 2026

Status verified date

Sep, 2026

Completion date

Feb, 2028

Anticipated

Primary completion date

Feb, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Medically healthy (based on self-report and study team review)
  • U.S. citizen or holding permanent resident status
  • English-speaking (able to provide consent and complete questionnaires)

Exclusion Criteria:

  • Current or past history of clinically significant neurological disorder or acquired neurological disease (e.g., stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified on the structural MRI)
  • History of inpatient psychiatric hospitalization
  • History of head trauma resulting in prolonged loss of consciousness; or a history of >3 grade I concussions
  • Current poorly controlled headaches, including intractable or frequent migraines
  • Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
  • History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
  • Possible pregnancy or plan to become pregnant in the next 6 months (self reported)
  • Any metal in the head or body
  • Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)
  • Dental implants
  • Permanent retainers
  • Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions
  • Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions
  • Current use of medications known to substantially lower seizure threshold, specifically chlorpromazine, clozapine, bupropion, clomipramine, or maprotiline; or other medications at doses known to substantially lower seizure threshold in the judgment of the PI
  • Active scalp lesions, broken skin, or skin conditions at planned electrode sites that would preclude safe electrode application
  • Claustrophobia (a fear of small or closed places)
  • Back problems that would prevent lying flat for up to two hours

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Session A: Amplitude Modulation Specificity

hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order:

  • in-phase mTI (10 Hz)
  • mixed unipolar+HF
  • HF control (no envelope)
  • SHAM PRE 3 min / STIM 3 min / POST 3 min per condition

Adverse events assessment

experimental: Session B: Benchmarking

hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order:

  • in-phase mTI (10 Hz)
  • unipolar TES-TI 5 mA
  • unipolar TES-TI 8 mA
  • SHAM PRE 3 min / STIM 3 min / POST 3 min per condition

Adverse events assessment

experimental: Session C: Frequency Dependence

hdEEG setup; eyes-closed wakefulness 4 conditions in randomized order:

  • in-phase mTI at 10 Hz
  • in-phase mTI at 50 Hz
  • in-phase mTI at 130 Hz
  • SHAM PRE 3 min / STIM 3 min / POST 3 min per condition

Adverse events assessment

Interventions

TES-TI with hdEEG

4 conditions per session. Each condition will follow a standardized block structure consisting of 3 minutes pre-stimulation baseline, 3 minutes stimulation, and 3 minutes post-stimulation recording (PRE, STIM, POST)

Primary outcome measure

  • Change in band-limited, topography-resolved EEG spectral power during stimulation for conditions in Session A [ Time Frame: data collected for 3 minutes prior to stimulation and 3 minutes during stimulation for each of 4 conditions during Session A (approximately 3 hours long) ]
  • Change in band-limited, topography-resolved EEG spectral power during stimulation for conditions in Session B [ Time Frame: data collected for 3 minutes prior to stimulation and 3 minutes during stimulation for each of 4 conditions during Session B (approximately 3 hours long) ]
  • Change in band-limited, topography-resolved EEG spectral power during stimulation for conditions in Session C [ Time Frame: data collected for 3 minutes prior to stimulation and 3 minutes during stimulation for each of 4 conditions during Session C (approximately 3 hours long) ]

Central Contacts and Locations

Central contacts

MINT Study Team

608-263-4313mint@psychiatry.wisc.edu

Locations

University of Wisconsin - Madison

Recruiting

Madison, Wisconsin, United States, 53706

More Information

Sponsor

University of Wisconsin, Madison

Last update posted

Sep 23, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by University of Wisconsin, Madison on 2026-09-23. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.