Recruiting

ESP vs. SAP

Sponsor:

Sunnybrook Health Sciences Centre

Code:

NCT07756047

Conditions

Traumatic Rib Fracture(s)

Traumatic Rib Fracture

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Erector spinae plane catheter

Serratus plane catheter

Study Details

Brief summary:

Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid buildup, or even respiratory failure. A major reason for this is pain-patients avoid deep breathing and coughing, which worsens lung function. Good pain control helps prevent these complications.

Opioids are commonly used for pain but can cause problems such as slowed breathing, delirium, nausea, and longer time on a ventilator. Because of this, regional anesthesia (nerve blocks) is increasingly used to control pain while reducing opioid use. Common options include epidurals, paravertebral blocks, and newer techniques like erector spinae plane (ESP) and serratus anterior plane (SAP) blocks. Continuous catheter techniques are especially useful in trauma patients because they can provide ongoing pain relief and have fewer contraindications than epidurals.

The SAP block is done at the side of the chest and works well for rib fractures in the front and side. It may not work as well for fractures in the back, although trauma may sometimes allow the anesthetic to spread further than expected.

The ESP block is done near the spine and may cover a broader area, including both front and back of the chest. It is relatively easy to perform at the bedside and is considered safe. Studies suggest it provides pain relief similar to epidurals in some patients.

There is still limited evidence directly comparing continuous SAP and ESP catheters. Only one study (using single injections) suggests ESP may provide better pain relief. It is unclear whether that difference holds true with continuous infusions, or whether SAP might be preferable because it is easier and quicker to perform.

We propose a randomized trial comparing continuous ESP and SAP catheters in patients with rib fractures to determine which provides better pain control, reduces opioid use, improves breathing outcomes, and is easier to perform in routine practice.

Our hypotheses are that ESP will provide better pain relief, SAP will be easier and safer to place, and both techniques will reduce opioid use while maintaining good patient comfort and breathing.

Conditions

Traumatic Rib Fracture(s)

Traumatic Rib Fracture

Study ID

NCT07756047

Start date

Sep 9, 2026

Status verified date

Oct, 2026

Completion date

Jun 30, 2028

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age >18;
  • Traumatic rib fractures (unilateral or bilateral);
  • Minimum of 3 rib fractures per side;
  • Admitted to hospital for <72 hours
  • NRS pain score > 4 at rest or with movement for chest pain at the time of eligibility assessment

Exclusion Criteria:

  • Severe traumatic brain injury (Glasgow Coma Scale < 9);
  • Surgery performed/planned within 72 hours of catheter infusion start;
  • Uncontrolled coagulopathy;
  • Skin infection or anatomical abnormality (i.e. open fracture) at insertion sites;
  • Allergy to local anesthetic;
  • Chronic high dose opioid use preadmission (Morphine Equivalent Dose > 30mg per day);
  • Pregnancy;
  • Acute respiratory failure requiring intubation at enrolment;
  • Inability to comply with Intravenous Patient-Controlled Analgesia use;
  • Contraindications to nerve blocks
  • High likelihood of loss to follow-up

Study Design

Enrollment

66 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Erector spinae plane catheter

Participants receive erector spinae plane catheter

experimental: Serratus plane catheter

Participants receive serratus anterior plane catheter

Interventions

Erector spinae plane catheter

Participants receive erector spinae plane catheter infusion

Serratus plane catheter

Participants receive serratus plane catheter infusion

Primary outcome measure

  • Pain with movement [ Time Frame: 72 hours ]

Central Contacts and Locations

Locations

Sunnybrook Health Sciences Centre

Recruiting

Toronto, Ontario, Canada, M4N 3M5

Contacts

Principal Investigator:

Howard Meng, MD

More Information

Sponsor

Sunnybrook Health Sciences Centre

Last update posted

Oct 23, 2026

Last verified

Oct, 2026

Keywords

  • trauma
  • rib fracture
  • regional anesthesia
  • fascial plane catheter
  • acute pain

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-24. This information was provided to ClinicalTrials.gov by Sunnybrook Health Sciences Centre on 2026-10-23. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.