Recruiting

Creatine & Tyrosol

Sponsor:

Applied Science & Performance Institute

Code:

NCT07756658

Conditions

Tyrosol

Creatine

Endurance Performance

Cognition

Mood

Eligibility Criteria

Sex: Male

Age: 20 - 55

Healthy Volunteers: Accepted

Interventions

Tyrosol

Creatine Monohydrate

Resistant Dextrin

Study Details

Brief summary:

This study will be a randomized, double-blind, placebo-controlled trial. It will be conducted over a 8-week intervention investigating the effects of creatine (5g Creatine monohydrate); placebo control (5g resistant dextrin), and a combination group containing both creatine and tyrosol (5g creatine monohydrate + 150mg tyrosol/day). Endurance, strength, cognition, and fatigue resistance will be examined through repeated strength and endurance testing (described below).

Participants who pass initial screening will be invited on-site for day one (Visit 1) of testing where the participants will proceed with a series of tests which will include the following: (1) body composition; (2) mood and cognitive testing; (3) full-body strength testing; (4) 5RM (repetition maximum) bench press, leading to multiple sets of bench press (based on the previous weight) completed to failure; (5) finally, a time to exhaustion endurance test will be conducted followed by (6) repeat cognitive testing.

After the 8-week supplementation period (\~56-60 days), all original measures will be repeated as before in the same order (Visit 2). Approximately 24 hours later (Visit 3) participants will complete a questionnaire for muscle soreness remotely, and again at 48 hours post-Visit 2 (visit 4).

Conditions

Tyrosol

Creatine

Endurance Performance

Cognition

Mood

Study ID

NCT07756658

Start date

Sep 4, 2026

Status verified date

Sep, 2026

Completion date

Jan 17, 2027

Anticipated

Primary completion date

Jan 17, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 20 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy males aged 20-55
  • Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
  • Estimated VO2 max greater than the 40th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
  • Able to read and write in English
  • During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
  • During the study, subjects will not deviate from their normal daily routine unless it conflicts with study criteria. This includes maintaining their present workout routine and diet, without substantial changes.

Exclusion Criteria:

  • Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
  • Uncontrolled stage II hypertension or higher
  • Recent musculoskeletal injury (<3-months)
  • Recent orthopaedic surgery (<12-months)
  • History of or current malignancy
  • Previous gastrointestinal surgery within the past 12 months
  • Regular smoker
  • Regular drinker (>14 drinks per week)
  • Current use (within the past 5 weeks) of creatine supplements
  • Current use (within past 3 months) of Tyrosol supplementation
  • Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).
  • Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Factorial

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Tyrosol and Creatine

150mg Tyrosol (administered as 1 capsule, containing 150mg/capsule) + 5g of Creatine Monohydrate powder; taken daily

experimental: Creatine + Placebo

5g Creatine Monohydrate powder + 150mg Resistant dextrin capsules (administered as 1 capsule, containing 150mg/capsule) (placebo); taken daily

experimental: Placebo + placebo

5g of resistant dextrin powder (placebo) + 150mg Resistant dextrin capsules (administered as 1 capsule, containing 150mg/capsule) (placebo); taken daily

Interventions

Tyrosol

phenolic compound found in olive oil

Creatine Monohydrate

chemical produced naturally by the body used to rapidly regenerate ATP

Resistant Dextrin

A type of soluble dietary fiber that is resistant to digestion in the small intestine. It is a byproduct of the starch hydrolysis process, where starch is broken down into smaller chains of glucose molecules

Primary outcome measure

  • Mid Thigh Pull [ Time Frame: Performed one time at baseline (visit 1) and at day 56 (visit 2) ]
  • Bench Press 5 Repetition Max (RM) [ Time Frame: Performed one time at baseline (visit 1) and at day 56 (visit 2). ]
  • Bench Press Repetitions to Failure [ Time Frame: Performed one time at baseline (visit 1) and at day 56 (visit 2). ]
  • Muscle/aerobic endurance (Graded Cycling time to exhaustion) [ Time Frame: Performed one time at baseline (visit 1) and at day 56 (visit 2). ]

Central Contacts and Locations

Central contacts

Eric Sikorski, PhD

8138678888esikorski@theaspi.com

Gabe Wilson, PhD

8138678888gwilson@theaspi.com

Locations

Applied Science and Performance Institute

Recruiting

Tampa, Florida, United States, 33634

Contacts

Eric Sikorski, PhD

8138678888esikorski@theaspi.com

Gabe Wilson, PhD

8138678888gwilson@theaspi.com

Principal Investigator:

Eric Sikorski, PhD

More Information

Sponsor

Applied Science & Performance Institute

Last update posted

Sep 21, 2026

Last verified

Sep, 2026

Keywords

  • tyrosol
  • creatine
  • muscle strength
  • muscle endurance
  • muscle soreness
  • muscle performance
  • cognition
  • mood

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by Applied Science & Performance Institute on 2026-09-21. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.