Recruiting

Sage

Sponsor:

ESM Technologies, LLC

Code:

NCT07757529

Conditions

Cognitive Ability, General

Eligibility Criteria

Sex: All

Age: 40 - 60

Healthy Volunteers: Accepted

Interventions

SageXtra

Placebo

Study Details

Brief summary:

Sage (Salvia officinalis) has been reported to have antioxidant, anti-inflammatory, and neuroprotective properties. Several studies indicate that sage supplementation can improve cognitive function. However, more research is needed. The purpose of this study is to examine how sage supplementation affects cognitive function and reaction times in middle-aged men and women.

Conditions

Cognitive Ability, General

Study ID

NCT07757529

Start date

Feb 15, 2026

Status verified date

Aug, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Oct 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 60

Healthy Volunteers: Accepted

Inclusion Criteria:

  • BMI 18.5-34.9 (inclusive) with a goal of being < 30 on average
  • Subject agrees to maintain their existing dietary patterns throughout the study period.
  • Subject agrees to refrain from alcohol, caffeine, and strenuous exercise for 24 hours before each test day.
  • Subject is willing and able to comply with the study protocol.
  • Has given voluntary, written, informed consent to participate in the study.

Exclusion Criteria:

  • Individuals with a personal history of a psychiatric disorder.
  • Individuals who are determined to have liver, renal, cardiovascular, or other metabolic disease.
  • Current or recent (< 4 weeks) use of any dietary supplements (e.g., choline, lecithin, ginseng, ginkgo biloba, ashwagandha, Bacopa Monnieri, Paullina cupana, Rhodiola rosea, L-theanine, omega-3 fats, Prevagen, etc.), or currently prescribed medications (e.g., Adderall, Mydayis, Ritalin, Concerta, Mythylin, Provigil, Namenda), that may affect cognitive function (focus, concentration, memory, reaction time, energy, etc.).
  • Alcohol consumption (>2 standard alcoholic drinks/day or >10 drinks/week) or drug abuse/dependence (including regular marijuana or THC use).
  • Currently a smoker.
  • Allergy or sensitivity to study product ingredients.
  • Individuals who are cognitively impaired and/or who are unable to give informed consent.
  • Any other condition which, in the PI's opinion, may adversely affect the subject's ability to complete the study, its measurements, or pose a significant risk to the subject.

Study Design

Enrollment

64 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Active

333 mg/day of SageXtra sage extract powder in two #0 capsules (167 mg/capsule).

placebo comparator: Placebo

333 mg/day of methylcellulose powder in two #0 capsules.

Interventions

SageXtra

333 mg/day of SageXtra sage extract powder in two #0 capsules (167 mg/capsule).

Placebo

333 mg/day of methylcellulose powder in two #0 capsules.

Primary outcome measure

  • COMputerized Mental Performance ASsessment System (COMPASS) Test Battery [ Time Frame: 4 weeks and 8 weeks ]

Central Contacts and Locations

Central contacts

Richard B. Kreider, Ph.D.

(979) 458-1498rbkreider@tamu.edu

Christopher Rasmussen, M.S.

(979) 458-1498crasmussen@tamu.edu

Locations

Exercise & Sport Nutrition Lab - Texas A&M University

Recruiting

College Station, Texas, United States, 77843

Contacts

Richard B. Kreider, Ph.D.

(979) 458-1498rbkreider@tamu.edu

Christopher Rasmussen, M.S.

(979) 458-1498crasmussen@tamu.edu

Principal Investigator:

Richard B. Kreider, Ph.D.

More Information

Sponsor

ESM Technologies, LLC

Last update posted

Aug 11, 2026

Last verified

Aug, 2026

Keywords

  • cognitive function
  • sage extract

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-29. This information was provided to ClinicalTrials.gov by ESM Technologies, LLC on 2026-08-11. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.