Recruiting

Spatial Selective Attention

Sponsor:

University of South Florida

Code:

NCT07765186

Conditions

Bilateral Cochlear Implants

Hearing Loss, Bilateral

Healthy

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Existing bilateral cochlear implants

Normal Hearing Control

Study Details

Brief summary:

Understanding speech in restaurants and other noisy environments is the most common complaint from the more than 60 million Americans with hearing impairment. Succeeding in such environments requires a listener to first segregate sound sources and then selectively attend to the source of interest. This study examines how individual auditory spatial cues (interaural time differences and interaural level differences) support spatial selective attention, the cortical processes that underlie this ability, and how these processes are modulated by task demands. Participants with normal hearing and participants who use bilateral cochlear implants will perform listening tasks while brain and physiological responses are recorded (electroencephalography, functional near-infrared spectroscopy, pupillometry, and, for normal-hearing participants only, functional magnetic resonance imaging). The findings will provide new insights into the mechanisms of spatial selective attention and help guide clinical solutions for cochlear implant users, individuals with hearing impairment more generally, and older normal-hearing adults who have difficulty understanding speech in noisy environments.

Conditions

Bilateral Cochlear Implants

Hearing Loss, Bilateral

Healthy

Study ID

NCT07765186

Start date

Oct 22, 2025

Status verified date

Aug, 2026

Completion date

Jul, 2030

Anticipated

Primary completion date

Apr, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults with normal hearing, confirmed by audiometric assessment (thresholds within 20 dB HL of normal through 8 kHz), OR adults with bilateral cochlear implants who have used their implants for at least one year
  • Native speakers of American English
  • Normal or corrected-to-normal vision

Exclusion Criteria:

  • Known neurological disorders
  • For fMRI sessions (normal-hearing participants only): contraindications to MRI scanning; cochlear implant users do not complete MRI sessions

Study Design

Enrollment

80 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

other: Bilateral Cochlear Implant Users

Adults with existing bilateral cochlear implants (implanted and using their devices for at least one year). Participants complete the discrimination and selective-attention auditory paradigms with manipulated spatial cues while combined EEG, fNIRS, and pupillometry are recorded. No fMRI is collected in this arm due to device safety concerns.

other: Normal Hearing Controls

Adults with audiometrically confirmed normal hearing (thresholds within 20 dB HL of normal through 8 kHz). Participants complete three auditory attention paradigms (working memory, discrimination, selective attention) with manipulated spatial cues, under combined EEG, fNIRS, and pupillometry sessions and fMRI sessions.

Interventions

Existing bilateral cochlear implants

Participants in this arm are recruited from a population who have existing bilateral cochlear implants. The implants are the participants' own clinical devices, used as clinically programmed; no investigational device or modification is provided by the study. Auditory attention tasks are presented with manipulated spatial cues (interaural time differences, interaural level differences, or HRTFs).

Normal Hearing Control

Control group recruited from the normal hearing population. Participants perform the same auditory attention tasks with manipulated spatial cues (interaural time differences, interaural level differences, or HRTFs) under EEG/fNIRS/pupillometry and fMRI.

Primary outcome measure

  • EEG [ Time Frame: 2 hours ]
  • NIRS [ Time Frame: 2 hours ]
  • Pupillometry [ Time Frame: 2 hours ]
  • MRI [ Time Frame: 2 hours ]
  • Discrimination (DISCR) [ Time Frame: 2 hours ]

Central Contacts and Locations

Central contacts

Christopher A Brown, PhD

412-670-2772cb43@usf.edu

Locations

University of South Florida, PCD Building, Room 3008A

Recruiting

Tampa, Florida, United States, 33620

Contacts

Christopher A Brown, PhD

412-670-2772cb43@usf.edu

More Information

Sponsor

University of South Florida

Last update posted

Aug 14, 2026

Last verified

Aug, 2026

Keywords

  • spatial hearing
  • auditory selective attention
  • interaural level difference
  • interaural time difference
  • cochlear implant
  • EEG
  • fNIRS
  • fMRI
  • pupillometry
  • speech in noise

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of South Florida on 2026-08-14.