Recruiting
Phase 1

Pemefolacianine

Sponsor:

Sunil Singhal

Code:

NCT07772895

Conditions

Lung Cancer (Locally Advanced or Metastatic)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Pemefolacianine Cohort 1 in Part A

Pemefolacianin Cohort 2 in Part B

Study Details

Brief summary:

The aim of this Phase 1b study is to investigate the safety and fluorescence signal of a single dose of Pemefolacianine for Injection, a novel fluorescence imaging agent developed by Nanjing Nuoyuan Medical Devices Co., Ltd (Nuoyuan Medical), administered by slow intravenous (IV) in patients undergoing surgical thoracoscopy and/or RATS (Robot-Assisted Thoracoscopic Surgery) resection of lung cancer. Safety is the primary objective of this study, followed by evaluation of the fluorescence signal as it relates to dose level and dosing time interval which will not be used for decision-making in the surgical resection in this study.

Conditions

Lung Cancer (Locally Advanced or Metastatic)

Study ID

NCT07772895

Start date

Mar 11, 2026

Status verified date

Mar, 2026

Completion date

Mar 11, 2027

Anticipated

Primary completion date

Mar 11, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Male or Female subjects greater than 18 years of age inclusive, at the time of signing the informed consent.
  • Have a primary diagnosis, or a high clinical suspicion, for cancer in the lung based on CT, biopsy, or other imaging.
  • Are scheduled to undergo surgical thoracoscopy or open surgery (thoracotomy) and resection of the lung.
  • If of childbearing potential, the patient must have a negative serum pregnancy test at screening, on Day 1 prior to Pemefolacianine for Injection administration, as well as using a medically acceptable form of contraception
  • Ability to understand the requirements of the study, provide written informed consent and authorization of use and disclosure of protected health information, and agree to abide by the study restrictions and to return for the required assessments

Exclusion Criteria:

  • Contraindications for surgery or any medical condition that in the opinion of the investigator could significantly jeopardize the safety of the subject
  • No planned surgical use of any other fluorescent optical imaging agent, or exposure to another optical imaging agent within 8 weeks prior to surgery (e.g., Cytalux)
  • History of any drug-related hypersensitivity or anaphylactic reactions, including those attributed to indocyanine green (ICG) or other agents used in the study, or known shellfish allergies.
  • Known sensitivity to fluorescent light
  • Patients with impaired renal function as defined by a creatinine clearance (CrCl) <60 mL/min at Screening, according to the Cockcroft-Gault formula ((140 - age) × body weight/plasma creatinine × 72 (× 0.85 for female)
  • History, or presence in the ECG at Screening, of any clinically significant abnormalities including cardiac conduction abnormalities such as Fridericia's corrected QTc interval (QTcF) > 470 ms
  • History of radiation therapy to the chest
  • Received a systemic investigational drug of any kind for any indication within 4 weeks or 5 half-lives prior to administration of Pemefolacianine for Injection and/or the patient has received Pemefolacianine for Injection previously
  • Total bilirubin level >1.5 times upper limit of normal at screening
  • Aspartate aminotransferase (AST)/serum glutamic-oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT)/serum glutamic-pyruvic transaminase (SGPT) > 2.5 times the upper limit of normal (ULN) at screening
  • The patient is pregnant, breast feeding, or plans to become pregnant within 6 months of the administration of Pemefolacianine for Injection or has a positive serum pregnancy test at Screening or a positive urine pregnancy test on the day of surgery or day of admission for female subjects of childbearing potential

Study Design

Enrollment

12 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Pemefolacianine Cohort 1

The dose of Pemefolacianine for Injection planned to be administered to the first cohort of patients is 0.02 mg/kg.

experimental: Pemefolacianine Cohort 2

The patients in second cohort were planned to receive dose Pemefolacianine for Injection at 0.04 mg/kg.

Interventions

Pemefolacianine Cohort 1 in Part A

Enrolled subjects arrive at the infusion center for their infusions up to 8-36hours before the scheduled surgery to receive their injection of Pemefolacianine for Injection. cohorts 1 patients will receive dose of 0.02 mg/kg

Pemefolacianin Cohort 2 in Part B

Enrolled subjects arrive at the infusion center for their infusions up to 8-36hours before the scheduled surgery to receive their injection of Pemefolacianine for Injection. cohorts 2 patients will receive dose of 0.04 mg/kg

Primary outcome measure

  • Number of participants with treatment-related adverse events as assessed by CTCAE v5.0 [ Time Frame: Day 1 through Day 30 ]

Central Contacts and Locations

Locations

University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Azra Din, MPH

215-615-7980azra.din@pennmedicine.upenn.edu

More Information

Sponsor

Sunil Singhal

Last update posted

Aug 19, 2026

Last verified

Mar, 2026

Keywords

  • Lung Nodule
  • Lung cancer

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Sunil Singhal on 2026-08-19.