Recruiting

Ketorolac, Tylenol, Nerve Block

Sponsor:

University of Chicago

Code:

NCT07773155

Conditions

Surgery, Upper Extremity

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Toradol

Oxycodone

Study Details

Brief summary:

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.

Conditions

Surgery, Upper Extremity

Study ID

NCT07773155

Start date

Mar 17, 2025

Status verified date

Aug, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Age 18 years or older
2. Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago.
3. Undergoing procedure with regional nerve block

Exclusion Criteria:

1. Age less than 18 years
2. Concomitant chronic opioid use
3. Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture
4. Medical contraindication to ketorolac use, including pregnancy
5. Undergoing multiple concurrent surgical procedures
6. Unable to communicate numerical pain score

Study Design

Enrollment

120 participants

Anticipated

Allocation

Non randomized

Intervention Model

Sequential

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Non-Opioid

Regional Nerve Block + Ketorolac (Toradol) + Tylenol (acetaminophen)

active comparator: Opioid

Regional Nerve Block + Oxycodone (5mg, 10 tablets) + Tylenol (acetaminophen)

Interventions

Toradol

Regional Nerve Block + Toradol + Acetaminophen

Oxycodone

Regional Nerve Block + Oxycodone + Acetaminophen

Primary outcome measure

  • Postoperative Pain, as measured by the Numeric Pain Scale [ Time Frame: 2 days, 1 week and 2 weeks post op ]

Central Contacts and Locations

Central contacts

Locations

University of Chicago

Recruiting

Chicago, Illinois, United States, 60637

More Information

Sponsor

University of Chicago

Last update posted

Aug 19, 2026

Last verified

Aug, 2026

Keywords

  • Wrist Surgery, Hand Surgery, Pain Management

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Chicago on 2026-08-19.