Recruiting
Phase 2

BL1107

Sponsor:

Bausch & Lomb Incorporated

Code:

NCT07778888

Conditions

Dry Eye Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

BL1107

Study Details

Brief summary:

Trial RX01-BL1107-1202 is designed to identify the lowest effective concentration of BL1107 required for complete resolution of conjunctival hyperemia in participants with DED. Participants will be masked to concentration of BL1107 received.

Conditions

Dry Eye Disease

Study ID

NCT07778888

Start date

Oct 19, 2026

Status verified date

Nov, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Documented diagnosis of dry eye disease
  • Conjunctival hyperemia in both eyes, without clinical signs of infection or allergic conjunctivitis

Exclusion Criteria:

  • Any active ocular disease
  • Anticipated wearing of contact lenses during study

Additional criteria per protocol

Study Design

Enrollment

20 participants

Anticipated

Intervention Model

Sequential

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: BL1107 is sterile ophthalmic solution to be administered at varying concentrations

Interventions

BL1107

BL1107 topical ocular solution

Primary outcome measure

  • Primary Part 1: Proportion of participants with complete resolution in conjunctival hyperemia at 30 minutes, in each evaluated concentration of BL1107. [ Time Frame: Assessed at 30 minutes ]
  • Primary Part 2: Proportion of participants with complete resolution in conjunctival hyperemia at 8 hours, in each evaluated concentration of BL1107 [ Time Frame: Assessed at 8 hours ]

Central Contacts and Locations

Central contacts

Johnson Varughese

9089271162Johnson.Varughese@bausch.com

Locations

Site 101

Recruiting

Newport Beach, California, United States, 92663

More Information

Sponsor

Bausch & Lomb Incorporated

Last update posted

Nov 10, 2026

Last verified

Nov, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-11. This information was provided to ClinicalTrials.gov by Bausch & Lomb Incorporated on 2026-11-10. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.