Recruiting

Midline Catheter & Long Peripheral Catheter

Sponsor:

Albany Medical College

Code:

NCT07779317

Conditions

Difficult Vein Access

Emergency Department Patients

Nurses Role

Midline Catheter

Ultrasound Assistance

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ultrasound-Guided Single-Lumen Midline Catheter

Ultrasound-Guided Long Peripheral Intravenous Catheter

Study Details

Brief summary:

Obtaining intravenous (IV) access is one of the most common procedures performed in the emergency department (ED). IV access is necessary for many aspects of patient care, including blood tests, administration of medications and intravenous fluids, and diagnostic imaging. However, some patients have difficult intravenous access (DIVA), making it challenging to successfully place an IV catheter. Difficulty obtaining IV access can lead to delays in diagnosis and treatment, prolonged emergency department stays, multiple needle punctures, and increased patient discomfort.

Several specialized IV devices are available for patients with DIVA. Two commonly used ultrasound-guided devices are long peripheral intravenous catheters and single-lumen midline catheters. Both devices are inserted into veins using ultrasound guidance, but they differ in catheter length and expected duration of use. Long peripheral IV catheters are commonly used in emergency departments but may fail relatively quickly. Midline catheters may remain functional for longer periods and may reduce the need for additional IV insertions during a patient's hospital stay. However, these devices have traditionally been inserted by specialized clinicians, such as members of vascular access teams, rather than by bedside emergency department nurses, who perform most vascular access procedures in many emergency departments.

The purpose of this study is to compare ultrasound-guided single-lumen midline catheters with ultrasound-guided long peripheral IV catheters when both procedures are performed by specially trained bedside emergency department nurses. The study will evaluate whether midline catheters can be inserted as successfully and as safely as long peripheral IV catheters in adult emergency department patients with difficult intravenous access.

Participants will be randomly assigned to receive either an ultrasound-guided single-lumen midline catheter or an ultrasound-guided long peripheral IV catheter. Researchers will compare the two devices by measuring procedural success, catheter-related complications, catheter dwell time, completion of care using the original device, and patient satisfaction.

The results of this study may help determine whether bedside emergency department nurses with training and experience in ultrasound-guided vascular access can successfully use single-lumen midline catheters in routine clinical practice. The study will also evaluate which vascular access device provides the best balance of safety, reliability, and patient experience for emergency department patients with difficult intravenous access. This information may help guide future recommendations for vascular access device selection in the emergency department.

Conditions

Difficult Vein Access

Emergency Department Patients

Nurses Role

Midline Catheter

Ultrasound Assistance

Study ID

NCT07779317

Start date

Aug 11, 2026

Status verified date

Aug, 2026

Completion date

Mar, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults 18 years of age or older
  • Presenting to the Albany Medical Center Emergency Department
  • Require intravenous access
  • Have difficult intravenous access (DIVA) defined by at least one of the following:
  • Two failed attempts at landmark-based or ultrasound-guided peripheral vascular access performed by qualified emergency department staff
  • A history of or active comorbid condition associated with difficult intravenous access, including:
  • Implanted vascular access port (current or previous)
  • End-stage renal disease with dialysis fistula
  • Sickle cell disease
  • Current or previous intravenous drug use
  • Self-reported difficult intravenous access plus one of the following:
  • A history of requiring two or more IV attempts during a previous healthcare encounter (self-reported or documented in the medical record)
  • A previous requirement for a rescue vascular access device after failed IV access, including:
  • Ultrasound-guided peripheral IV
  • Midline catheter
  • Peripherally inserted central catheter (PICC)
  • Central venous catheter (CVC)
  • Intraosseous catheter

Exclusion Criteria:

  • Younger than 18 years of age
  • Prisoners
  • Non-English-proficient patients
  • Patients in whom the device cannot be adequately stabilized because of tissue injury or treatment involving the available extremities (including burns, complex humeral fractures, or dialysis fistulas)
  • Patients who lack the capacity to provide informed consent and do not have an authorized legal representative available
  • Patients without an identifiable target vein on ultrasonography
  • Patients known to be pregnant
  • Previous enrollment in the study
  • Previous withdrawal from the study
  • Presentation during a period when no study proceduralists are available
  • Patients for whom the informed consent and enrollment process could delay time-sensitive medical care

Study Design

Enrollment

292 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Ultrasound-Guided Single-Lumen Midline Catheter

Participants randomized to this arm will undergo insertion of an ultrasound-guided single-lumen midline catheter performed by a trained bedside emergency department registered nurse. The proceduralist will select the catheter gauge and insertion site according to institutional practice.

active comparator: Ultrasound-Guided Long Peripheral Intravenous Catheter

Participants randomized to this arm will undergo insertion of an ultrasound-guided long peripheral intravenous catheter performed by a trained bedside emergency department registered nurse. The proceduralist will select the catheter gauge and insertion site according to institutional practice.

Interventions

Ultrasound-Guided Single-Lumen Midline Catheter

A BD PowerGlide™ 10-cm single-lumen midline catheter (18G or 20G) will be inserted under ultrasound guidance using standard institutional procedures. The catheter may be placed in the cephalic, basilic, deep brachial, or forearm veins according to proceduralist judgment.

Ultrasound-Guided Long Peripheral Intravenous Catheter

A BD Insyte™ Autoguard 4.78-cm peripheral intravenous catheter (18G or 20G) will be inserted under ultrasound guidance using standard institutional procedures. The catheter may be placed in the cephalic, basilic, deep brachial, or forearm veins according to proceduralist judgment.

Primary outcome measure

  • Procedural Success of Ultrasound-Guided Vascular Access Device Insertion [ Time Frame: Immediately following the vascular access procedure. ]

Central Contacts and Locations

Central contacts

Alexander Bracey, MD

518-262-6328braceya@amc.edu

Locations

Albany Medical Center Hospital

Recruiting

Albany, New York, United States, 12208

Contacts

Alexander Bracey, MD

518-262-6328braceya@amc.edu

More Information

Sponsor

Albany Medical College

Last update posted

Aug 25, 2026

Last verified

Aug, 2026

Keywords

  • DIVA
  • Ultrasound-Guided Vascular Access
  • Midline Catheter
  • Single-Lumen Midline Catheter
  • Long Peripheral Intravenous Catheter
  • Ultrasound-Guided Peripheral Intravenous Catheter
  • Emergency Department Nursing
  • Emergency Nursing
  • Vascular Access Device
  • Ultrasound-Guided Intravenous Access

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Albany Medical College on 2026-08-25.