Recruiting

Observational Study

Sponsor:

Massachusetts General Hospital

Code:

NCT07780890

Conditions

Fuchs Endothelial Corneal Dysfunction

Open Angle Glaucoma (OAG)

Dry Eye Disease (DED)

Keratoconus

Lasik Eye Surgery

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The overall goal of this study is to develop Brillouin microscope as a novel tool for measuring biomechanical and hydration properties of human tissues in vivo.

Conditions

Fuchs Endothelial Corneal Dysfunction

Open Angle Glaucoma (OAG)

Dry Eye Disease (DED)

Keratoconus

Lasik Eye Surgery

Study ID

NCT07780890

Start date

Aug 18, 2026

Status verified date

Aug, 2026

Completion date

Sep 1, 2027

Anticipated

Primary completion date

Sep 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy volunteers with normal eyes
  • Visual acuity between +2 to -6 diopters

Exclusion Criteria:

  • History of refractive or cataract surgery
  • History of ocular disease
  • Active non-ophthalmic systemic disease

Study Design

Enrollment

90 participants

Anticipated

Interventions and Outcome Measures

Arms

Control Group

Healthy Subjects

Patient Group

Patient Subjects (Fuch's endothelial dystrophy, Corneal guttae, Open-angle glaucoma, Dry eye disease, Keratoconus, post-LASIK)

Primary outcome measure

  • Number of subjects to successfully complete Brillouin measurement without serious unanticipated adverse events related to application of the device. [ Time Frame: Through completion of the single study visit, approximately 1-2 hours ]

Central Contacts and Locations

Central contacts

Soyeon (Selina) Ahn, PhD

3396009736sahn14@mgh.harvard.edu

Seok-Hyun Yun, PhD

6177688704syun@mgh.harvard.edu

Locations

Massachusetts General Brigham

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Soyeon (Selina) Ahn, PhD

3396009736sahn14@mgh.harvard.edu

Seok-Hyun Yun, PhD

6177688704syun@mgh.harvard.edu

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Aug 25, 2026

Last verified

Aug, 2026

Keywords

  • cornea
  • biomechanics
  • brillouin microscopy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-08-25.