Recruiting

Long COVID

Sponsor:

University of North Carolina, Chapel Hill

Code:

NCT07781501

Conditions

SARS CoV-2 Post-Acute Sequelae

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms.

Study Details

Brief summary:

This study will examine how common Long COVID is and how symptoms may persist over time in people who have previously had COVID-19. Researchers will collect information about participants' health and symptoms through questionnaires and may collect saliva and other non-invasive oral samples. The study will also examine biological factors in these samples that may be associated with persistent symptoms. The goal is to better understand why some people develop Long COVID and identify factors that may help predict who is more likely to experience persistent symptoms.

Conditions

SARS CoV-2 Post-Acute Sequelae

Study ID

NCT07781501

Start date

Sep 4, 2024

Status verified date

Aug, 2026

Completion date

Dec 31, 2029

Anticipated

Primary completion date

Dec 31, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age 18 to 75 years.
  • Previous laboratory-confirmed SARS-CoV-2 infection.
  • Willing and able to provide informed consent.
  • Able to complete study questionnaires and study procedures.

Exclusion Criteria:

  • Current severe periodontal disease with bleeding gums.
  • Current oral herpes flare, aphthous ulcer, or oral candidiasis (thrush).
  • Oral viral or bacterial infection within the previous 30 days.
  • Dry mouth that would prevent adequate saliva collection.
  • Active alcohol or drug abuse.
  • Medical or genetic syndrome or developmental delay that would prevent completion of study procedures or questionnaires.

Study Design

Enrollment

500 participants

Anticipated

Interventions and Outcome Measures

Arms

COVID-19+

Adults who have previously had COVID-19 and may be experiencing ongoing symptoms or changes in their health following infection.

Interventions

This study is observational. Only patients who have previously tested positive for SARS-CoV-2 infection or are experiencing ongoing symptoms.

Other:

Primary outcome measure

  • Salivary Proteomic Profile [ Time Frame: During active infection through three months post infection ]
  • Salivary Metabolomic Profile [ Time Frame: During active infection through three months post infection ]
  • Validated Health Questionnaires: SBQ-LC (Symptom Burden Questionnaire - Long COVID) [ Time Frame: During active infection through three months post infection ]
  • Validated Health Questionnaire: C19-YRS (COVID-19 Yorkshire Rehabilitation Scale) [ Time Frame: During active infection through three months post infection ]
  • Validated Health Questionnaire: EFTER-COVID survey [ Time Frame: During active infection through three months post infection ]

Central Contacts and Locations

Central contacts

Laura A Jacox, PhD, DMD, MS

+1 847-702-0988ljacox@live.unc.edu

Jeannene L Matthews, MA, M.Ed., CCC-SLP

+1 919-357-5999jeannene_matthews@med.unc.edu

Locations

University of North Carolina

Recruiting

Chapel Hill, North Carolina, United States, 27599-7555

Contacts

Laura A Jacox, PhD, DMD, MS

+1 847-702-0988ljacox@live.unc.edu

Jeannene L Matthews, MA, M.Ed., CCC-SLP

+1 919-537-5999jeannene_matthews@med.unc.edu

Principal Investigator:

Laura A Jacox, PhD, DMD, MS

More Information

Sponsor

University of North Carolina, Chapel Hill

Last update posted

Aug 24, 2026

Last verified

Aug, 2026

Keywords

  • COVID-19
  • SARS-CoV-2
  • Long COVID

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of North Carolina, Chapel Hill on 2026-08-24.