Recruiting
Phase 4

Buprenorphine vs. Morphine

Sponsor:

Icahn School of Medicine at Mount Sinai

Code:

NCT07786012

Conditions

Cesarean Delivery

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Interventions

buprenorphine

morphine

Study Details

Brief summary:

In this study the researchers are randomizing pregnant patients coming for elective cesarean delivery to receive either intrathecal buprenorphine or morphine for their analgesia.

Conditions

Cesarean Delivery

Study ID

NCT07786012

Start date

Oct 7, 2026

Status verified date

Oct, 2026

Completion date

Aug, 2028

Anticipated

Primary completion date

Aug, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19+

Healthy Volunteers: Not accepted

Inclusion Criteria:

\- Presenting for singleton elective cesarean delivery at term gestation.

Exclusion Criteria:

  • allergy to buprenorphine or morphine
  • will not have neuraxial anesthesia
  • chronic pain conditions
  • opiate based medications

Study Design

Enrollment

180 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Buprenorphine

Patients receive 60 mcg buprenorphine as a part of their spinal medications.

active comparator: Morphine

Patients receive 125 mcg morphine as a part of their spinal medications

Interventions

buprenorphine

60 mcg buprenorphine intrathecal

morphine

125mcg morphine intrathecal

Primary outcome measure

  • Morphine equivalents administered within 24 hours after spinal administration [ Time Frame: 24 hours ]

Central Contacts and Locations

Central contacts

Daniel Katz

212-241-7475daniel.katz@mountsinai.org

Locations

Mount Sinai Hospital

Recruiting

New York, New York, United States, 10029

Contacts

Daniel Katz, MD

212-241-7475daniel.katz@mountsinai.org

Principal Investigator:

Daniel Katz

More Information

Sponsor

Icahn School of Medicine at Mount Sinai

Last update posted

Oct 16, 2026

Last verified

Oct, 2026

Keywords

  • Cesarean Delivery
  • Pregnancy
  • postop pain

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-17. This information was provided to ClinicalTrials.gov by Icahn School of Medicine at Mount Sinai on 2026-10-16. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.