Recruiting

Knee Cartilage Repair

Sponsor:

Smith & Nephew, Inc.

Code:

NCT07786207

Conditions

Knee Injuries

Joint Surface Knee Lesions

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Marketed Product - MP01

Other Surgical Treatments

Study Details

Brief summary:

This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage. Information will be collected from patients undergoing knee surgery for cartilage damage and entered into a large database that reflects routine clinical practice ("real-world" data). The data collected will be used to support future research and improve understanding of treatment outcomes for knee cartilage repair.

Conditions

Knee Injuries

Joint Surface Knee Lesions

Study ID

NCT07786207

Start date

Sep 23, 2026

Status verified date

Jun, 2026

Completion date

Mar 31, 2034

Anticipated

Primary completion date

Mar 31, 2034

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Prospective Subjects

  • Provides written informed consent.
  • Is eighteen (18) years of age or older at time of consent and considered skeletally mature in the opinion of the investigator.
  • Scheduled to undergo knee cartilage surgery with the Marketed Product-MP01 OR other knee cartilage repair surgery.
  • For subjects having other knee cartilage repair surgery:

\- Falls within Marketed Product-MP01 on label indication: Knee chondral or osteochondral lesions (ICRS grade III and above, 1-7cm2) in patients with or without mild-moderate knee osteoarthritis (K/L 0-3).
  • Has an electronic device and is willing and able to use the device to complete the 'Electronic Clinical Outcomes Assessment' (eCOA).
  • Willing and able to complete all requested questionnaires.
  • Able to follow instructions and deemed capable of completing registry protocol requirements.

Retrospective/Prospective Subjects

  • Provides written informed consent.
  • Was eighteen (18) years of age or older at time of surgery and considered skeletally mature at that time in the opinion of the investigator.
  • Underwent knee cartilage repair surgery with the Marketed Product-MP01 within the last 2-years.
  • Has an electronic device and is willing and able to use the device to complete the eCOA.
  • Willing and able to complete all requested questionnaires.
  • Able to follow instructions and deemed capable of completing registry protocol requirements.
  • Consents to retrospective data being collected from pre-operative visit(s) and surgery through to the point of consent as available in their medical notes.

Exclusion Criteria:

  • History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate/coral derivatives.
  • Is actively participating in a cartilage repair clinical trial.
  • For subjects having other knee cartilage repair surgery:

\- Treatment will be on patellar lesion(s).
  • Has participated previously in this registry (with the index or contralateral knee).
  • Meets the definition of a Vulnerable Subject per ISO 14155 Section 3.56.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Marketed Product - MP01

Participants who are having knee cartilage surgery with Marketed Product - MP01

Other Knee Cartilage Procedures

Participants who are having knee cartilage surgery with a procedure other than using Marketed Product - MP01

Interventions

Marketed Product - MP01

Marketed Product - MP01 is a medical device used in the treatment of knee-joint surface lesions.

Other Surgical Treatments

Any other surgical procedures used in the treatment of knee-joint surface lesions that fall within the Marketed Product - MP01 on label indication.

Primary outcome measure

  • International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score change from Baseline to 24-months [ Time Frame: Baseline and 24 months ]

Central Contacts and Locations

Central contacts

Judith Horner

+44 (0)1482 673251Judith.Horner@smith-nephew.com

Laura Everson

Laura.Everson@smith-nephew.com

Locations

Orthopedic Centers of Colorado

Recruiting

Parker, Colorado, United States, 80134

Contacts

Abby Watkins

abby.watkins@occ-ortho.com

Principal Investigator:

Justin Newman, MD

CAO Research Foundation

Recruiting

Washington D.C., District of Columbia, United States, 20036

Contacts

Stacy Tam

stacy.tam@caoresearch.org

Principal Investigator:

Scott Faucett, MD, MS

The Orthopaedic Research Foundation, Inc.

Recruiting

Indianapolis, Indiana, United States, 46278

Contacts

Melanie Glover

mglover@orthoindy.com

Principal Investigator:

Corey Kendall, MD

Penn Highlands DuBois

Recruiting

DuBois, Pennsylvania, United States, 15801

Contacts

Jared Ham

JSHam@phhealthcare.org

Principal Investigator:

Matthew Valacallo, MD

More Information

Sponsor

Smith & Nephew, Inc.

Last update posted

Oct 8, 2026

Last verified

Jun, 2026

Keywords

  • Knee cartilage lesions
  • joint surface lesions of the knee

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-09. This information was provided to ClinicalTrials.gov by Smith & Nephew, Inc. on 2026-10-08. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.