Recruiting

Osteopathic Manipulative Treatment

Sponsor:

Lake Erie College of Osteopathic Medicine

Code:

NCT07786467

Conditions

No Disease or Condition is Being Directly Studied

The Focus of the Study in Healthy Volunteers

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Osteopathic Manipulation

Osteopathic manipulation

Sham

Study Details

Brief summary:

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.

Conditions

No Disease or Condition is Being Directly Studied

The Focus of the Study in Healthy Volunteers

Study ID

NCT07786467

Start date

Sep, 2026

Status verified date

Aug, 2026

Completion date

Oct, 2027

Anticipated

Primary completion date

Oct, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Willing to receive OMT
  • Willing to receive influenza vaccine
  • Older than 18 years of age

Exclusion Criteria:

  • Younger than 18 years of age
  • Pregnancy or lactation
  • Unwilling to receive the influenza vaccine
  • Unwilling to receive OMT
  • Open wounds
  • Bone fractures
  • Moderate to severe osteoporosis
  • Severe COPD
  • Current/active infections
  • Mononucleosis infection within past 6 months
  • Liver cirrhosis
  • Cancer or metastatic disease
  • History of DVT, PE, or blood clotting disorder
  • Individuals taking blood thinning medications, except aspirin
  • Having a pacemaker or other thoracic medical devices

Study Design

Enrollment

50 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

active comparator: Thoracic pump only

Only thoracic inlet myofascial release

sham comparator: No intervention

No intervention pre- or post-influenza vaccination.

experimental: Complete lymphatic pumping

Multiple sites of OMT to occur post-influenza vaccination.

Interventions

Osteopathic Manipulation

In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.

Osteopathic manipulation

In this intervention, participants will receive osteopathic manipulation 2 days prior to influenza vaccination, the day of influenza vaccination, and 4 days post-influenza vaccination. The OMT will include thoracic inlet myofascial release, pectoral traction, rib raising, doming of the diaphragm, pelvic diaphragm release, popliteal fossa release, plantar myofascial release, passive Miller thoracic pump, liver pump, and spleen pump.

Sham

In this intervention, participants will receive no osteopathic treatments

Primary outcome measure

  • Hemagglutinin inhibition assay [ Time Frame: baseline and 4 weeks post vaccination ]

Central Contacts and Locations

Central contacts

David Duriancik, Ph.D.

814-860-5139dduriancik@lecom.edu

Irv Freeman, J.D., Ph.D.

724-552-2870ifreeman1@lecom.edu

Locations

Plaza 38 Medical Offices

Recruiting

Erie, Pennsylvania, United States, 16509

Contacts

Jacob Cukierski, DO

814-860-8414jcukierski@lecom.edu

Stephany Esper, DO

814-860-8463sesper@lecom.edu

Principal Investigator:

David Duriancik, Ph.D.

More Information

Sponsor

Lake Erie College of Osteopathic Medicine

Last update posted

Sep 23, 2026

Last verified

Aug, 2026

Keywords

  • Osteopathic Manipulation
  • Influenza vaccine
  • Aging
  • Body composition

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by Lake Erie College of Osteopathic Medicine on 2026-09-23. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.