Recruiting

EMBED

Sponsor:

Yale University

Code:

NCT07793383

Conditions

Opioid Abuse (Disorder)

Clinical Decision Support

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Refined EMBED CDS

Provider alert that nurse completed COWS

Study Details

Brief summary:

This study is stage 2, round 3 of a larger study which refines and optimizes the EMBED clinical decision support (CDS) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with opioid use disorder. See NCT03658642

Conditions

Opioid Abuse (Disorder)

Clinical Decision Support

Study ID

NCT07793383

Start date

Aug 17, 2026

Status verified date

Sep, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Emergency department patient
  • 18 years of age or older
  • Moderate to severe opioid use disorder

Exclusion Criteria:

  • Under 18 years of age
  • Pregnant
  • Currently receiving medication for opioid use disorder

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Sequential

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Refined EMBED CDS

EMBED CDS refined based on previous results

experimental: Refined EMBED plus provider alert the nurse completed COWS

Alert to provider in Epic that the nurse completed COWS

Interventions

Refined EMBED CDS

Refined EMBED CDS

Provider alert that nurse completed COWS

Provider alert that nurse completed COWS

Primary outcome measure

  • Proportion of encounters with Buprenorphine initiation in the ED [ Time Frame: Trial round start to end up to 3 months ]

Central Contacts and Locations

Central contacts

Edward Melnick, MD, MHS

203-785-4363edward.melnick@yale.edu

Laurel Buchanan, MA

203-785-4363laurel.buchanan@yale.edu

Locations

Yale New Haven Shoreline Medical Center

Recruiting

Guilford, Connecticut, United States, 06437

Yale New Haven Hospital- St. Raphael

Recruiting

New Haven, Connecticut, United States, 06510

Yale New Haven Hospital

Recruiting

New Haven, Connecticut, United States, 06520

More Information

Sponsor

Yale University

Last update posted

Sep 25, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-26. This information was provided to ClinicalTrials.gov by Yale University on 2026-09-25. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.