Recruiting

Environmental Pollutants

Sponsor:

Abigail Mancuso

Code:

NCT07802691

Conditions

Infertility (IVF Patients)

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Not accepted

Interventions

Environmental Pollutant Detox

Study Details

Brief summary:

Environmental pollutants are present in many aspects of everyday life. Exposures to common household products, such as food packaging and cookware, may affect reproductive health. Many of these environmental toxicants are known as "endocrine disrupting chemicals" because they can interfere with the body's hormone systems. Our study aims to create a guide that explains common sources of environmental toxicants and offer practical steps to reduce exposure. The investigators will evaluate how well participants understand this information and how consistently the intervention is maintained over time.

To assess whether these changes reduce environmental pollutant exposure, the investigators will measure levels of two classes of toxicants within the urine and blood at the beginning, middle and end of the study in patients struggling with infertility that are planning in vitro fertilization (IVF) treatment. The investigators will also measure the same chemicals in follicular fluid (fluid which surrounds developing eggs in the ovary) and seminal fluid (fluid which surrounds the sperm in semen) and compare these levels to samples from similar patients who did not receive the education or make environmental changes. The goal of this project is to determine whether simple changes to reduce exposure to environmental pollutants can lower chemical levels of toxicants in the body and whether this may ultimately impact outcomes for patients undergoing in vitro fertilization.

Conditions

Infertility (IVF Patients)

Study ID

NCT07802691

Start date

Oct 26, 2026

Status verified date

Nov, 2026

Completion date

Feb 28, 2028

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Not accepted

Inclusion criteria:

\- Unexplained infertility diagnosis (no identifiable male or female causes to infertility)

Exclusion criteria:

  • Female age 38 years and older
  • Male age 45 and older
  • Diagnosis of diminished ovarian reserve
  • Diagnosis of PCOS/PMOS
  • Smoking or drug use in either male and/or female partner
  • BMI >40 in either partner
  • Patients using donor oocytes/donor sperm/donor embryos

Study Design

Enrollment

60 participants

Anticipated

Intervention Model

Single group

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Plastic Detox

All participants recruited

Interventions

Environmental Pollutant Detox

All patients will be provided education on environmental pollutants and provide practical steps to reduce exposure.

Primary outcome measure

  • Concentration of Bisphenol in urine [ Time Frame: 12 weeks ]
  • Concentration of PFAS in blood [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

Locations

University of Iowa

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

More Information

Sponsor

Abigail Mancuso

Last update posted

Nov 9, 2026

Last verified

Nov, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-10. This information was provided to ClinicalTrials.gov by Abigail Mancuso on 2026-11-09. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.