Recruiting

Glaucoma Drainage Device

Sponsor:

Duke University

Code:

NCT07803536

Conditions

GLAUCOMA 1, OPEN ANGLE, D (Disorder)

Glaucoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ripcord removal

Study Details

Brief summary:

This is a research study to find out if removing the ripcord from a glaucoma drainage device more than 3 months after it has been placed has any effect on intraocular pressure. Participation in research studies is voluntary.

The ripcord will be removed at a routine glaucoma care visit and intraocular pressure will be measured before removal, 30 minutes following, and at 1 week, 6 weeks and 3-month intervals during regular clinic visits.

Conditions

GLAUCOMA 1, OPEN ANGLE, D (Disorder)

Glaucoma

Study ID

NCT07803536

Start date

Dec, 2026

Status verified date

Nov, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Sep, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age > 18 years
  • Placement of Ahmed Clear Path or Baervelt drainage device with ripcord > 3 months
  • Diagnosis of Glaucoma, under active management at Duke Eye Center Glaucoma Clinic
  • Ripcord suture still in place and accessible for removal
  • Able to provide written informed consent
  • IOP > 10 mm Hg

Exclusion Criteria:

  • Active ocular infection or conjunctivitis in either eye
  • Inability to undergo ripcord removal procedure
  • Scheduled for further glaucoma surgery

Study Design

Enrollment

80 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Ripcord removal

Interventions

Ripcord removal

Patients who have had a ripcord in place for greater than 3 months postoperatively will undergo ripcord removal in the office.

Primary outcome measure

  • Change in intraocular pressure (IOP) [ Time Frame: Immediately after, 1 week, 6 weeks and 3-month intervals ]

Central Contacts and Locations

Central contacts

Jonathan Shepherd

(919) 681-3937j_shepherd0829@email.campbell.edu

Locations

Duke University Eye Center

Recruiting

Durham, North Carolina, United States, 27705

Contacts

Jonathan Shepherd

(919) 681-3937j_shepherd0829@email.campbell.edu

Principal Investigator:

Leon W Herndon, MD

More Information

Sponsor

Duke University

Last update posted

Nov 9, 2026

Last verified

Nov, 2026

Keywords

  • glaucoma drainage device
  • ripcord

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-10. This information was provided to ClinicalTrials.gov by Duke University on 2026-11-09. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.