Recruiting

Steroid Injection

Sponsor:

University of Chicago

Code:

NCT07804446

Conditions

Osteoarthitis

Osteoarthritic Knee Pain

Osteoarthritis (OA)

Osteoarthritis (OA) of the Knee

Osteoarthritis in the Knee

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Interventions

Anteromedial Injection

Anterolateral Injection

Study Details

Brief summary:

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

1. Be randomly divided into getting their steroid injection on the inside or outside of their knee.
2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Conditions

Osteoarthitis

Osteoarthritic Knee Pain

Osteoarthritis (OA)

Osteoarthritis (OA) of the Knee

Osteoarthritis in the Knee

Study ID

NCT07804446

Start date

Aug 31, 2026

Status verified date

Aug, 2026

Completion date

May 1, 2027

Anticipated

Primary completion date

Apr 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 40
  • Clinical diagnosis of knee OA with predominant medial compartment symptoms
  • Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
  • Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
  • Able to provide informed consent
  • Able to complete phone, email, or MyChart follow-ups in English

Exclusion Criteria:

  • Predominant lateral compartment OA or patellofemoral-only OA
  • Inflammatory arthritis (RA, gout flare, etc.)
  • Suspected or confirmed joint infection or overlying cellulitis
  • Prior knee arthroplasty on the index knee
  • Planned surgery for index knee within 12-week follow-up
  • Inability to complete follow-up assessments
  • Other clinician-determined contraindication to CSI

Study Design

Enrollment

140 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Anterolateral

These patients will receive their corticosteroid injections on their anterolateral knees.

active comparator: Anteromedial

This group of patients will receive injections on the anteromedial side of their knee.

Interventions

Anteromedial Injection

If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.

Anterolateral Injection

If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.

Primary outcome measure

  • Numeric Pain Rating Scale [ Time Frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection ]
  • Knee Osteoarthritis and Outcome Score-Joint Replacement [ Time Frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection ]

Central Contacts and Locations

Central contacts

Malik J Scott, B.A.

773-834-3531mjscott1@uchicago.edu

Locations

Bolingbrook Clinic

Recruiting

Bolingbrook, Illinois, United States, 60440

Contacts

Brandon Pardi, M.D.

630-759-1248brandon.pardi.md@adventhealth.com

Principal Investigator:

Brandon Pardi, M.D.

Hyde Park Clinic

Recruiting

Chicago, Illinois, United States, 60637

Contacts

Sara J Wallace, M.D./M.P.H.

773-834-3531swallace2@bsd.uchicago.edu

Malik Scott, B.A.

mjscott1@uchicago.edu

Principal Investigator:

Sara JS Wallace, M.D./M.P.H.

La Grange Clinic

Recruiting

La Grange, Illinois, United States, 60525

Contacts

Sara JS Wallace, M.D./M.P.H.

773-834-3531swallace2@bsd.uchicago.edu

Principal Investigator:

Sara JS Wallace, M.D./M.P.H.

Orland Park Clinic

Recruiting

Orland Park, Illinois, United States, 60462

Contacts

Sara JS Wallace, M.D./M.P.H.

888-824-0200swallace2@bsd.uchicago.edu

Malik J Scott, B.A.

mjscott1@uchicago.edu

Principal Investigator:

Sara JS Wallace, M.D./M.P.H.

Woodridge Clinic

Recruiting

Woodridge, Illinois, United States, 60517

Contacts

Brandon Pardi, M.D.

630-759-1248brandon.pardi.md@adventhealth.com

Principal Investigator:

Brandon Pardi, M.D.

More Information

Sponsor

University of Chicago

Last update posted

Sep 4, 2026

Last verified

Aug, 2026

Keywords

  • osteoarthritis
  • arthritis
  • corticosteroid
  • steroid injection
  • pain
  • pain control
  • pain survey
  • knee
  • knee arthritis
  • knee osteoarthritis
  • knee pain
  • knee injection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Chicago on 2026-09-04.