Recruiting

Jovi Patch

Sponsor:

Signal Relief

Code:

NCT07825558

Conditions

General Menstrual Discomfort

Eligibility Criteria

Sex: Female

Age: 18 - 50

Healthy Volunteers: Not accepted

Interventions

Jovi Patch

Sham Patch

Study Details

Brief summary:

This pilot study is testing whether a thin, flexible, drug-free patch called the Jovi Patch (powered by Signal Relief) can help reduce general menstrual discomfort (pain and related symptoms during periods).

The patch contains no medication, wires, or batteries. It uses special micro-metal particles that are thought to interact with the body's natural electrical signals related to pain. Researchers will compare an active version of the patch to a look-alike sham (inactive) patch.

About 50 pre-menopausal women ages 18-50 who have menstrual discomfort (pain score greater than 4 on a 0-10 scale) will be randomly assigned to one of two groups:

Active patch group (larger group) Sham patch group

Participants will wear their assigned patch during six menstrual cycles (starting the day before their period begins and continuing through the week of flow). After three cycles, women in the sham group will switch to the active patch for the remaining three cycles so researchers can also look at the effects of switching.

The main question is whether more women using the active patch achieve at least a 30% reduction in their pain scores compared with those using the sham patch. The study will also track changes in how much menstrual symptoms interfere with daily life, use of pain medications, and any side effects (such as skin irritation).

Participation lasts through six menstrual cycles. The overall study is expected to take up to 12 months.

Conditions

General Menstrual Discomfort

Study ID

NCT07825558

Start date

May 8, 2026

Status verified date

Sep, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

Jun, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 50

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Pre-menopausal female subjects aged 18 -50 years.
  • Currently seeking treatment for general menstrual discomfort
  • NPRS scale score > 4 at baseline.
  • Able and willing to provide informed consent in English without the assistance of an interpreter.

Exclusion Criteria:

  • Receiving other investigational agents or on another clinical trial.
  • Subject has implantable pain device, pacemaker, defibrillator, or other neuromodulation implantable device.
  • Known to be pregnant, or plan to become pregnant in the next 6 months
  • Current Jovi/Signal Relief users

Study Design

Enrollment

50 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

active comparator: Active Jovi Patch

Participants receive the active Jovi Patch (powered by Signal Relief), a non-invasive, drug-free flexible wellness patch containing conductive particle arrays. The patch is worn during six consecutive menstrual cycles (or three cycles if crossing over from sham).

sham comparator: Sham Patch

Participants receive a matching inactive (sham) patch that is identical in appearance to the active Jovi Patch but does not contain the conductive particle arrays. After three cycles, these participants cross over to the active Jovi Patch for the remaining three cycles.

Interventions

Jovi Patch

Non-invasive, drug-free flexible wellness patch containing conductive particle arrays

Sham Patch

Matching inactive (sham) patch that is identical in appearance to the active Jovi Patch but does not contain the conductive particle arrays

Primary outcome measure

  • Proportion of Participants Achieving at Least 30% Change in NPRS Score [ Time Frame: Baseline to end of treatment (after 6 menstrual cycles) ]

Central Contacts and Locations

Central contacts

Ashley Trymbiski

4452008090atrymbiski@gmail.com

Locations

Redeemer Health

Recruiting

Meadowbrook, Pennsylvania, United States, 19046

Contacts

Ashley Trymbiski

4452008090atrymbiski@gmail.com

Principal Investigator:

Stacy Krisher, MD

More Information

Sponsor

Signal Relief

Last update posted

Sep 17, 2026

Last verified

Sep, 2026

Keywords

  • Menstrual discomfort
  • Jovi Patch
  • Signal Relief

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-18. This information was provided to ClinicalTrials.gov by Signal Relief on 2026-09-17.