Recruiting
Early Phase 1

Erector Spinae Plane Block

Sponsor:

UCLA

Code:

NCT07826936

Conditions

Erector Spinae Plane Block

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Bupivacaine (erector spinae plane block)

Study Details

Brief summary:

Currently, the standard treatment of nonsurgical abdominal pain in the Emergency Department (ED) includes narcotic pain medication. This can be addictive and contributes to the current opioid epidemic. Recent studies have shown that the Erector Spinae Plane Block (ESPB) is an alternative approach to achieving abdominal analgesia without the use of any systemic pain medications. It is a regional nerve block that can be used by emergency medicine physicians by injecting anesthetic into the erector spinae plane under ultrasound guidance, which effectively anesthetizes the abdomen. This procedure is within the scope of practice of Emergency Medicine residents, fellows, and attendings who have received training in Point-of-Care Ultrasound (POCUS) and who have also received specialized training on how to perform the ESPB under ultrasound guidance. Adult patients will be screened for intractable abdominal pain (persistent pain despite systemic pain medications) and eligibility to receive the nerve block (for example, patients cannot be pregnant, must be able to verbalize pain and satisfaction scores, and must have no contraindication to receiving the nerve block). In this study, the investigators will perform a small pilot study to determine how effective the ESPB is compared to systemic pain medications, and how easy or difficult it is to perform the ESPB in the Emergency Department as a means of controlling abdominal pain.

Conditions

Erector Spinae Plane Block

Study ID

NCT07826936

Start date

Oct 11, 2024

Status verified date

Sep, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Over 18 years of age
  • Abdominal pain that is intractable, defined as pain persisting despite administration of more than one dose of narcotic medication
  • Nonsurgical abdominal pain, determined by either a benign abdominal exam not warranting a computed tomography (CT) scan, or a CT scan showing no identifiable surgical process
  • Patient may present from the Emergency Department (ED) or may be an admitted inpatient

Exclusion Criteria:

  • Under 18 years of age
  • Pregnant, confirmed by a positive pregnancy test sent on all female patients of childbearing age presenting with abdominal pain
  • Psychiatric patients
  • Unable to verbalize a pain score, or impaired decision-making capacity (e.g., obtunded, intoxicated, lethargic, critically ill, intubated, or cognitively impaired)
  • Any contraindication to nerve blocks, such as infection overlying the injection site, a bleeding disorder, or an allergy to anesthetic
  • Surgical abdomen requiring serial abdominal exams

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Erector Spinae Plane Block (ESPB)

Patients receive the erector spinae plane block (ESPB) via ultrasound-guided injection of bupivacaine, with systemic analgesics provided as needed if pain persists.

no intervention: Standard Systemic Pain Medication

Patients receive standard-of-care systemic pain medication (non-opioid analgesics or opioids such as Norco/hydrocodone-acetaminophen).

Interventions

Bupivacaine (erector spinae plane block)

Ultrasound-guided erector spinae plane block (ESPB) performed with injection of bupivacaine, administered in place of standard systemic pain medication.

Primary outcome measure

  • Change in Pain Score [ Time Frame: Baseline (time of consent), 30 minutes post-intervention, and 3 hours post-intervention ]

Central Contacts and Locations

Central contacts

Locations

UC Irvine, Department of Emergency Medicine

Recruiting

Orange, California, United States, 92868

More Information

Sponsor

University of California, Irvine

Last update posted

Sep 17, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-18. This information was provided to ClinicalTrials.gov by University of California, Irvine on 2026-09-17.