Recruiting

Radioacoustic Imaging

Sponsor:

University of Oklahoma

Code:

NCT07832617

Conditions

Proton Therapy

Radiation Therapy, Secondary Skin Reactions

Liver Cancer

Prostate Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Radiacoustic Imaging w/Ultrasound.

Study Details

Brief summary:

The purpose of this study is to test a new imaging technology called radioacoustic imaging (RAI) that may help doctors see where radiation is being delivered during proton therapy.

During proton therapy, the radiation treatment produces very small sound signals inside the body. This study will use special ultrasound sensors placed on the outside of the body to detect these signals. The information collected may allow researchers to create a picture showing where the radiation dose is being delivered in the body and how much radiation is reaching the treatment area.

The goal is to determine whether this technology can safely and accurately measure radiation during proton therapy without requiring any additional procedures or radiation exposure.

Conditions

Proton Therapy

Radiation Therapy, Secondary Skin Reactions

Liver Cancer

Prostate Cancer

Study ID

NCT07832617

Start date

Jun 10, 2026

Status verified date

Sep, 2026

Completion date

Jun, 2030

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients at least >18years old
  • Patients referred to OUHSC SCC for SOC PT
  • Patients receiving treatment for indications where RAI data collection is feasible (e.g., liver and prostate)
  • Willingness and ability to provide a documented informed consent

Exclusion Criteria:

  • Patients with contraindications for ultrasound coupling (e.g., extensive open wounds or skin conditions at transducer placement sites).
  • Patients whose treatment plan or setup prevents the practical application of the RAI system without interfering with standard clinical care
  • Patients with implanted electronic devices (e.g., pacemakers) in the treatment region if there is any concern of device interference, even though the RAI system is passive.

Study Design

Enrollment

24 participants

Anticipated

Interventions and Outcome Measures

Arms

Proton Therapy In Vivo

This prospective clinical trial will evaluate the use of RAI in 24 cancer patients, including 12 patients with liver cancer and 12 patients with prostate cancer, using a noninvasive device. The device consists of a small ultrasound transducer placed on the participant's body that delivers low-intensity sound signals through the body to evaluate the treatment.

Interventions

Radiacoustic Imaging w/Ultrasound.

A robotic arm will position the ultrasound matrix array on the lower abdomen.

Primary outcome measure

  • Percentage of Liver Cancer Patients With Successful Respiratory Motion From Radiacoustic Imaging Tracking. [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Lead Onco Nurse

(405) 271-3016SCC-IIT-Office@ouhsc.edu

Yong Chen, PhD

(405) 271-3016Yong-Chen@ou.edu

Locations

OU Health Stephenson Cancer Center

Recruiting

Oklahoma City, Oklahoma, United States, 73117

Contacts

Yong Chen, PhD

405-271-3016Yong-Chen@ou.edu

More Information

Sponsor

University of Oklahoma

Last update posted

Sep 22, 2026

Last verified

Sep, 2026

Keywords

  • RAI

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by University of Oklahoma on 2026-09-22. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.