Recruiting

Velocity-Loss Resistance Training

Sponsor:

University of Miami

Code:

NCT07840508

Conditions

Activity, Motor

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Interventions

10% Velocity-Loss Threshold Resistance Training

30% Velocity-Loss Threshold Resistance Training

Study Details

Brief summary:

This study will compare the effects of velocity-loss resistance training at 10% and 30% velocity loss thresholds on measures of muscle strength and power and tests of daily performance in older adults with Parkinson's disease.

Conditions

Activity, Motor

Study ID

NCT07840508

Start date

Sep 25, 2026

Status verified date

Sep, 2026

Completion date

Dec 30, 2026

Anticipated

Primary completion date

Dec 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Parkinson's Disease Hoehn \& Yahr Stages 1-3
  • Able to walk 50 meters unassisted
  • Able to understand and communicate in English

Exclusion Criteria:

  • Uncontrolled cardiovascular or other neuromuscular disease that prevent participation in a training program
  • Any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, or other serious concomitant medical illness
  • Unresolved injury or surgery to the upper or lower limbs that prevents weight training.

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: 10% Velocity-Loss Threshold Resistance Training

Participants will receive velocity-based resistance training at 10% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks.

experimental: 30% Velocity-Loss Threshold Resistance Training

Participants will receive velocity-based resistance training at 30% velocity-loss threshold, twice per week for at least 24 sessions for up to 12 weeks.

Interventions

10% Velocity-Loss Threshold Resistance Training

Participants will receive a total of twenty-four 45-minutes in-person training sessions at 10% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises.

30% Velocity-Loss Threshold Resistance Training

Participants will receive a total of twenty-four 45-minutes in-person training sessions at 30% velocity-loss threshold, twice per week using three sets of eight repetitions per set. During training participants will be allowed 1-minute rests between sets. Exercises will include four upper-body exercises and 2 lower-body exercises.

Primary outcome measure

  • Change in neuromuscular performance as measured by 1-repetition maximum (1RM) [ Time Frame: Baseline, 12 weeks ]
  • Change in neuromuscular performance as measured by Watts [ Time Frame: Baseline, 12 weeks ]

Central Contacts and Locations

Central contacts

Ethan A Elkins, MS

3052844173exe453@miami.edu

Joseph F. Signorile, PhD

3052843105jsignorile@miami.edu

Locations

Laboratory of Neruomuscular Research and Active Aging

Recruiting

Coral Gables, Florida, United States, 33147

Contacts

Joseph F Signorile, PhD

305-284-3105jsignorile@miami.edu

Principal Investigator:

Joseph Signorile, PhD

More Information

Sponsor

University of Miami

Last update posted

Sep 28, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-29. This information was provided to ClinicalTrials.gov by University of Miami on 2026-09-28. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.