Recruiting

MRI Techniques

Sponsor:

Laura Walkup

Code:

NCT07845708

Conditions

Muskuloskeletal Diseases

Healthy

Respiratory

Eligibility Criteria

Sex: All

Age: 5+

Healthy Volunteers: Accepted

Interventions

MRI

Study Details

Brief summary:

In this research study we want to learn about new ways to use MRI (Magnetic Resonance Imaging) to take clearer pictures of the lungs. We will be using types of MRI called UTE (Ultra Short Echo Time) and bSSFP (balanced Steady-State Free Precession) as well as traditional MRI. We also want to collect images and health information about lungs that are healthy or those in people with different kinds of lung, muscular, and bone diseases. This collection will help us in the future to better understand lung variations in health and disease.

Conditions

Muskuloskeletal Diseases

Healthy

Respiratory

Study ID

NCT07845708

Start date

Jun 17, 2025

Status verified date

Sep, 2026

Completion date

Jun, 2030

Anticipated

Primary completion date

Jun, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 5+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Age ≥ 5 years

Exclusion Criteria:

  • History of any comorbidity reviewed at the Screening phone call that, in the opinion of the investigator, might confound the results of the study or pose an additional risk to the subject.
  • Standard MRI exclusion criteria as set forth by the CCHMC Radiology Department and IRC.
  • Pregnancy

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Interventions

MRI

This intervention uses specialized MRI sequences, UTE and bSSFP, alongside traditional MRI to capture high-resolution images of lung structure and function. These sequences are optimized for imaging pulmonary tissues and airspaces, which is not typical in standard clinical MRI protocols. The study focuses on both healthy participants and those with lung, muscular, and bone diseases to evaluate variations in lung imaging.

Primary outcome measure

  • Develop, optimize, and validate of 1H MRI sequences for assessment of lung structure and function [ Time Frame: Through study completion, an average of 5 years ]
  • Generate preliminary bSSFP UTE 1H MRI data in healthy individuals and individuals with thoracic musculoskeletal disorders. [ Time Frame: Through study completion, an average of 5 years ]

Central Contacts and Locations

Central contacts

Ashley Borden, MPH

5136360143ashley.borden@cchmc.org

Locations

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Contacts

Ashley Borden, MPH

5136360143ashley.borden@cchmc.org

More Information

Sponsor

Laura Walkup

Last update posted

Sep 29, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-30. This information was provided to ClinicalTrials.gov by Laura Walkup on 2026-09-29. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.