Recruiting

Noah Labs Vox

Sponsor:

Noah Labs

Code:

NCT07870395

Conditions

Heart Failure

Chronic Heart Failure

Chronic Heart Disease

Eligibility Criteria

Sex: All

Age: 22+

Healthy Volunteers: Not accepted

Interventions

Daily Voice Recording

Study Details

Brief summary:

VOICE-HF is a clinical study designed to evaluate the performance of a novel non-invasive software device (Noah Labs Vox) that uses vocal characteristics to estimate DHF risk and has strong potential for clinical success. This study will compare the performance of Noah Labs Vox with the contemporary performance of commonly used weight-based remote monitoring rules and applications to determine efficacy and safety.

Conditions

Heart Failure

Chronic Heart Failure

Chronic Heart Disease

Study ID

NCT07870395

Start date

Oct 15, 2026

Status verified date

Oct, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 22+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥22
  • HF diagnosis (Stage C)
  • DHF event within prior 180 days

Exclusion Criteria:

  • Monitoring with implantable volume or pressure monitoring devices, or
  • Planned cardiac surgery or major intervention (e.g., LVAD or transplant), or
  • Otherwise inability or unwillingness to comply with study procedures.

Study Design

Enrollment

450 participants

Anticipated

Interventions and Outcome Measures

Arms

Voice-Based Monitoring Group

All participants receive standard heart failure care as per local standard of care, plus daily voice monitoring via a mobile application. Patients record voice samples and answer symptom questions daily. Sites and participants are blinded to the results, which are analyzed retrospectively.

Interventions

Daily Voice Recording

Patients use the mobile app daily to record voice samples and answer optional wellness and symptom-related questions. Voice recordings are analyzed by an algorithm, which extracts vocal biomechanical features. Results are not shared with clinicians and participants during the study and are analyzed retrospectively after study completion.

Primary outcome measure

  • Performance Outcome Measure [ Time Frame: From enrollment to the end of follow up of 6 months ]

Central Contacts and Locations

Central contacts

Leonhard Riehle MD, MD

+49 171 5547970leonhard.riehle@noah-labs.com

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Ameesh Isath, MBBS

617-732-6237aisath@bwh.harvard.edu

More Information

Sponsor

Noah Labs

Last update posted

Oct 27, 2026

Last verified

Oct, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-28. This information was provided to ClinicalTrials.gov by Noah Labs on 2026-10-27. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.