Recruiting

Olipop

Sponsor:

Ball State University

Code:

NCT07882264

Conditions

Healthy Participants

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Interventions

Prebiotic soda followed by high-fat meal

Control beverage followed by high-fat meal

Study Details

Brief summary:

We are examining whether consuming a fiber-enriched soda (Olipop) before a high-fat meal leads to a more favorable cardiometabolic response than when consuming a control beverage before the same high-fat meal.

Conditions

Healthy Participants

Study ID

NCT07882264

Start date

May 1, 2026

Status verified date

Oct, 2026

Completion date

Dec 1, 2027

Anticipated

Primary completion date

May 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

  • You are 18-50 years old
  • BMI is between 18.5-35.0 kg/m2 - this BMI requirement is due to our research aims.
  • You are not pregnant or expecting to become pregnant (females only).
  • You are not postmenopausal (females only).
  • You have not been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)
  • You have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • You do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily suspend use of anti-inflammatory drugs.
  • You do not use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs.
  • You do not have a pacemaker.
  • You do not have dietary restrictions prohibiting you from eating the provided meal (e.g., food allergies/intolerance to beef or sweet potato).
  • You have not used antibiotics or probiotics in the last month (probiotic containing foods like yogurt are allowed).
  • You do not use weight-loss medications (e.g., Ozempic, Wegovy)
  • You have not had any surgery that alters the stomach/gastrointestinal tract (e.g., gastric sleeve, gastric bypass).

Exclusion Criteria:

  • You are not 18-50 years old.
  • Your BMI is <18.5 or > 35.0 kg/m2 - this BMI requirement is due to our research aims
  • You are pregnant or expecting to become pregnant (females only).
  • You are postmenopausal (females only).
  • You have been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)
  • You have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • You regularly take anti-inflammatory drugs (more than 2x week) or are unable to temporarily suspend use of anti-inflammatory drugs.
  • You use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs
  • You have a pacemaker.
  • You do have dietary restrictions prohibiting you from eating the provided meal (e.g., food allergies/intolerance to beef or sweet potato).
  • You have used antibiotics or probiotics in the last month.
  • You use weight-loss medications (e.g., Ozempic, Wegovy).
  • You have had a surgery that alters the stomach/gastrointestinal tract (e.g., gastric sleeve, gastric bypass).

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Prebiotic Soda Consumption

During the prebiotic soda arm, participants will consume prebiotic fiber-enriched soda (Olipop) prior to a high-fat meal.

active comparator: Control Beverage

During the control arm, participants will consume a control beverage consisting of seltzer water, granulated sugar, and maltodextrin prior to a high-fat meal.

Interventions

Prebiotic soda followed by high-fat meal

Participants will consume 20 oz of Olipop cream soda and then eat a high-fat breakfast (two Jimmy Deans bowls).

Control beverage followed by high-fat meal

Participants will consume a control beverage (seltzer water with identical sugar and calories to Olipop drink) and then eat a high-fat breakfast (two Jimmy Deans bowls).

Primary outcome measure

  • Triglycerides [ Time Frame: Through the study completion, up to 1 year ]
  • sCD14 [ Time Frame: Through study completion, up to 1 year. ]
  • LBP [ Time Frame: Through the study completion, up to 1 year ]
  • HDL-C [ Time Frame: Through the study completion, up to 1 year ]
  • Glucose [ Time Frame: Through the study completion, up to 1 year ]
  • ApoB [ Time Frame: Through the study completion, up to 1 year ]
  • Insulin [ Time Frame: Through the study completion, up to 1 year ]

Central Contacts and Locations

Central contacts

Bryant Keirns, Principal Investigator

765-285-8356bryant.keirns@bsu.edu

Locations

Health Professions Building, Ball State University

Recruiting

Muncie, Indiana, United States, 47306

Contacts

Bryant Keirns, PhD

765-285-8356bryant.keirns@bsu.edu

More Information

Sponsor

Ball State University

Last update posted

Oct 20, 2026

Last verified

Oct, 2026

Keywords

  • Olipop
  • Prebiotic

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-21. This information was provided to ClinicalTrials.gov by Ball State University on 2026-10-20. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.