Recruiting

EpinephrinePhysiology-directed Epinephrine Dosing in Pediatric Cardiac Arrest

Sponsor:

Children's Hospital of Philadelphia

Code:

NCT07890610

Conditions

Cardiac Arrest (CA)

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of this study is to evaluate the physiologic response to epinephrine as an outcome discriminator in pediatric in-hospital cardiac arrest (IHCA). In addition, the investigators will determine optimal epinephrine dosing strategies based on the initial physiologic response to epinephrine, and to develop machine learning (ML) algorithms to guide intra-arrest therapy.

Conditions

Cardiac Arrest (CA)

Study ID

NCT07890610

Start date

Jul 1, 2024

Status verified date

Oct, 2026

Completion date

Jun 30, 2029

Anticipated

Primary completion date

Jun 30, 2029

Anticipated

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

Arrest in an ICU
Patients received chest compressions for at least 1 minute

Exclusion Criteria:

Lack of commitment to aggressive therapies (e.g., CPR performed as part of end-of-life care)
Brain death determination prior to CPR
Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes)
Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Study Design

Enrollment

1620 participants

Anticipated

Interventions and Outcome Measures

Arms

Pediatric Cardiac Arrests

Pediatric cardiac arrests requiring chest compressions for at least 1 minute occurring in an ICU identified as part of standard clinical operations.

Primary outcome measure

Return of Spontaneous Circulation (ROSC) lasting 20 minutes [ Time Frame: Duration of CPR event through 20 minutes after CPR ]

Central Contacts and Locations

Central contacts

Jessica Goldstein

215-590-1859 goldsteij1@chop.edu

CHOP RSC Clinical Research Program Manager

215-590-1859 grahamk1@chop.edu

Locations

CHOC

Recruiting

Orange, California, United States, 92868

Contacts

Jennifer Hayes

909-614-3592 jhayes@choc.org

Stanford Medicine Children's Health

Recruiting

Stanford, California, United States, 94305

Contacts

Felice Su

650-736-7632 felicesu@stanford.edu

Children's Hospital Colorado

Recruiting

Denver, Colorado, United States, 80045

Contacts

Carly Scahill

Carly.Scahill@childrenscolorado.org

Nemours Children's Health

Recruiting

Wilmington, Delaware, United States, 19803

Contacts

Yosef Levenbrown

201-390-4961 Yosef.Levenbrown@nemours.org

Children's Healthcare of Atlanta

Recruiting

Atlanta, Georgia, United States, 30303

Contacts

Stephanie Brown

216-333-3806 stephanie.rachelle.brown@emory.edu

Comer Children's Hospital

Recruiting

Chicago, Illinois, United States, 60637

Contacts

Priti Jani

773-702-6169 priti.jani@uchospitals.edu

Riley Children's Health

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Maria Frazier

937-272-5832 mfrazier7@iuhealth.org

Stead Family Children's Hospital

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

Sarah Haskell

319-353-6464 sarah-haskell@uiowa.edu

Boston Children's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Catherine Ross

785-766-7214 Catherine.Ross@childrens.harvard.edu

Washington University in St. Louis

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Ashley Turner

ashley.turner@wustl.edu

Cohen Children's Medical Center

Recruiting

New Hyde Park, New York, United States, 11040

Contacts

Todd Sweberg

718-470-3668 Tsweberg@northwell.edu

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Anita Sen

ais13@cumc.columbia.edu

UNC Children's Hospital

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

Afsaneh Pirzadeh

afsaneh_pirzadeh@med.unc.edu

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Contacts

Daniel Loeb

216-299-0004 Daniel.Loeb@cchmc.org

Nationwide Children's Hospital

Recruiting

Columbus, Ohio, United States, 43205

Contacts

John Jennings

614-722-4619 john.jennings@nationwidechildrens.org

Children's Hospital of Philadelphia

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Ryan Morgan

315-601-2252 morganr1@chop.edu

Dell Children's Medical Center

Recruiting

Austin, Texas, United States, 78723

Contacts

Hunter Daigle

512-550-7786 hunter.daigle@utexas.edu

Medical City Children's Hospital

Recruiting

Dallas, Texas, United States, 75230

Contacts

Tia Raymond

972-533-7175 tiaraymond@me.com

University of Texas Southwestern Medical Center

Recruiting

Dallas, Texas, United States, 75390

Contacts

Javier Lasa

Javier.Lasa@UTSouthwestern.edu

Children's Hospital of Richmond at VCU

Recruiting

Richmond, Virginia, United States, 23219

Contacts

Michelle Olson

804-628-5488 michelle.olson@vcuhealth.org

Seattle Children's

Recruiting

Seattle, Washington, United States, 98105

Contacts

Joan Roberts

206-987-5119 joan.roberts@seattlechildrens.org

Children's Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Andrea Maxwell

712-870-1959 amaxwell@mcw.edu

More Information

Sponsor

Children's Hospital of Philadelphia

Last update posted

Oct 22, 2026

Last verified

Oct, 2026

Keywords

Pediatric
Epinephrine

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-23. This information was provided to ClinicalTrials.gov by Children's Hospital of Philadelphia on 2026-10-22. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.