Recruiting
Phase 4

Iheezo vs. Lidocaine

Sponsor:

Retina Research Institute, LLC

Code:

NCT07895420

Conditions

No Condition

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

chloroprocaine HCL 3%

Subconjunctival Lidocaine

Study Details

Brief summary:

This will be a prospective, randomized, controlled non-inferiority trial comparing the efficacy of Iheezo versus subconjunctival 2% lidocaine in reducing intravitreal injection pain scores up to 24 hours after injection.

Conditions

No Condition

Study ID

NCT07895420

Start date

Oct 30, 2025

Status verified date

Sep, 2026

Completion date

Dec 30, 2026

Anticipated

Primary completion date

Dec 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • At least 1 previous intravitreal injection in the last 180 days from screening.

Exclusion Criteria:

  • History of more than 13 intravitreal injections.

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Iheezo

active comparator: Subconjunctival Lidocaine

Interventions

chloroprocaine HCL 3%

Topical anesthetic for intravitreal injection

Subconjunctival Lidocaine

Procedural anesthetic for intravitreal injection

Primary outcome measure

  • Pain Scores [ Time Frame: 4 hourse ]

Central Contacts and Locations

Central contacts

Locations

The Retina Institute

Recruiting

Glen Carbon, Illinois, United States, 62034

Contacts

The Retina Institute

Recruiting

Chesterfield, Missouri, United States, 63017

Contacts

The Retina Institute

Recruiting

City of Saint Peters, Missouri, United States, 63376

Contacts

The Retina Institute

Recruiting

St Louis, Missouri, United States, 63128

Contacts

Research Director, M.S. Pharm, MBA

314-367-1181justin.hyers@rc-stl.com

More Information

Sponsor

Retina Research Institute, LLC

Last update posted

Oct 26, 2026

Last verified

Sep, 2026

Keywords

  • Iheezo, pain scores, intravitreal injection

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-27. This information was provided to ClinicalTrials.gov by Retina Research Institute, LLC on 2026-10-26. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.