CO2 Laser & Ultraformer MPTUltraformer MPT Combined With Fractional CO2 Versus Fractional CO2 Alone for Facial Rejuvenation

Inclusion Criteria:

1. Female, aged 50 to 65 years.
2. Fitzpatrick skin phototype I to III on investigator clinical assessment.
3. Mild-to-moderate facial rhytides and lower-face/jawline laxity on investigator assessment, documented on standardized baseline photographs.
4. Stable weight (± 3 kg over the prior 6 months) with no planned major weight change.
5. Non-smoker (no current tobacco or nicotine smoking).
6. Able and willing to follow the pre-treatment skin-preparation, prophylaxis, and photoprotection regimen.
7. Able and willing to attend all study visits and phone checks and comply with pre- and post-treatment care.
8. Signed informed consent (English or French).

Exclusion Criteria:

1. Fitzpatrick phototype IV to VI.
2. Prior unilateral facial procedure, surgery, or trauma producing visible left-right asymmetry of the treatment zones.
3. Thin or angular facial morphology, prior facial fat grafting, buccal fat pad excision, or visible midface/temporal hollowing at baseline.
4. Prior HIFU, radiofrequency microneedling, Ultherapy, or ablative laser to the face within 12 months; facial filler in treatment zones within 6 months; neuromodulator within 3 months.
5. Active facial dermatosis or infection; keloid or hypertrophic scarring history; immunosuppression; isotretinoin within 6 months.
6. Pregnancy, planned pregnancy, or breastfeeding.
7. Planned or anticipated weight change greater than 5 kg, bariatric surgery, or major dental/orthognathic work during the study.
8. Any condition that, in the investigator's judgment, makes participation unsafe or data uninterpretable.