Recruiting

Observational Study

Sponsor:

Masonic Cancer Center, University of Minnesota

Code:

NCT07910019

Conditions

Prostate Carcinoma

Eligibility Criteria

Sex: Male

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Non-Interventional Study

Study Details

Brief summary:

This study collects, stores and analyzes blood specimens and information from people with prostate cancer. This may help researchers understand whether certain white blood cells involved in immunity differs between prostate cancer patients from various racial backgrounds.

Conditions

Prostate Carcinoma

Study ID

NCT07910019

Start date

Oct 8, 2026

Status verified date

Oct, 2026

Completion date

Nov 30, 2030

Anticipated

Primary completion date

Nov 30, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • AIM 1:

  • Diagnosis (or presumed diagnosis) of primary Prostate cancer
  • 18 years of age or older
  • Has a planned visit to a University of Minnesota Cancer Clinic
  • Willing and able to sign voluntary written consent

Exclusion Criteria:

  • AIM 1:

  • Inability or unwillingness to give written informed consent

Study Design

Enrollment

45 participants

Anticipated

Interventions and Outcome Measures

Arms

Observational

Patients undergo collection of blood samples and have their medical records reviewed on study. Patients may undergo collection of residual tissue samples, if available, on study.

Interventions

Non-Interventional Study

Non-interventional study

Primary outcome measure

  • Baseline natural cytotoxicity of CSPC and CRPC patients' natural killer cells [ Time Frame: Through study completion, an average of 1 year ]
  • Broad immune landscape [ Time Frame: Through study completion, an average of 1 year ]
  • Analysis of biopsy samples [ Time Frame: Through study completion, an average of 1 year ]
  • Effects on NK cells treated with IL-15, camB7-H3 TriKE, scFv PSMA TriKE, or camB7-H3/PSMA TriKE-PACC [ Time Frame: Through study completion, an average of 1 year ]
  • Ability of the 5 treatments to mitigate tumor burden [ Time Frame: Through study completion, an average of 1 year ]

Central Contacts and Locations

Locations

University of Minnesota/Masonic Cancer Center

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Nicholas A. Zorko

612-626-1422zorko004@umn.edu

Principal Investigator:

Nicholas A. Zorko

More Information

Sponsor

Masonic Cancer Center, University of Minnesota

Last update posted

Nov 2, 2026

Last verified

Oct, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-03. This information was provided to ClinicalTrials.gov by Masonic Cancer Center, University of Minnesota on 2026-11-02. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.