Recruiting

Myotonic Dystrophy

Sponsor:

Massachusetts General Hospital

Code:

NCT07912983

Conditions

Myotonic Dystrophy Type 1

Eligibility Criteria

Sex: All

Age: 14+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies. The investigators are interested in finding less invasive methods that reduce the need for muscle biopsies. The purpose of this research is to learn about the possibility of detecting and measuring the activity and severity of myotonic dystrophy by examining a urine sample and a blood sample, and performing muscle function testing. The information that is gathered from this study may help to evaluate, prevent, diagnose, treat, and improve the understanding of human myotonic dystrophy.

Conditions

Myotonic Dystrophy Type 1

Study ID

NCT07912983

Start date

Oct 26, 2026

Status verified date

Nov, 2026

Completion date

Aug, 2031

Anticipated

Primary completion date

Aug, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 14+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Individuals with myotonic dystrophy
  • Individuals without myotonic dystrophy
  • Ages 14 years and older

Exclusion Criteria:

  • State of immunosuppression
  • Coagulopathy
  • Use of anticoagulants within 60 days prior to blood draw

Study Design

Enrollment

64 participants

Anticipated

Interventions and Outcome Measures

Arms

Myotonic dystrophy

Unaffected

Primary outcome measure

  • Extracellular vesicle metabolite profile [ Time Frame: Five years ]

Central Contacts and Locations

Central contacts

Tamkin Shahraki, MD

617-726-7506tshahraki@mgh.harvard.edu

Locations

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Tamkin Shahraki, MD

617-726-7506tshahraki@mgh.harvard.edu

More Information

Sponsor

Massachusetts General Hospital

Last update posted

Nov 3, 2026

Last verified

Nov, 2026

Keywords

  • myotonic dystrophy
  • extracellular vesicles
  • metabolites
  • biomarkers
  • metabolomics
  • multi-omics

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-04. This information was provided to ClinicalTrials.gov by Massachusetts General Hospital on 2026-11-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.