Recruiting

Cognitive Motor Dissociation

Sponsor:

Columbia University

Code:

NCT07917728

Conditions

Traumatic Brain Injury (TBI) Patients

Intracerebral Hemorrhage

Subarachnoid Hemorrhage

Cardiac Arrest (CA)

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this research study is to evaluate whether a smartphone-enabled EEG (electroencephalography) system can be used to detect Cognitive Motor Dissociation (CMD) in patients with acute neurological injuries who appear unable to follow commands at the bedside. CMD occurs when a person may be conscious and able to understand instructions but cannot physically respond. The study will also examine whether CMD detection is associated with short-term and long-term recovery outcomes.

Conditions

Traumatic Brain Injury (TBI) Patients

Intracerebral Hemorrhage

Subarachnoid Hemorrhage

Cardiac Arrest (CA)

Study ID

NCT07917728

Start date

Oct 27, 2026

Status verified date

Oct, 2026

Completion date

Sep 1, 2029

Anticipated

Primary completion date

Dec 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Admitted for acute traumatic brain injury, intracerebral or subarachnoid hemorrhage, or cardiac arrest
2. Neurological examination per Coma Recovery Scale-Revised (CRS-R) criteria consistent with coma, vegetative state, or minimally conscious state minus (not explained by sedation)
3. Enrollment by day 7 post injury.

Exclusion Criteria:

1. EEG demonstrating ongoing seizures or ictal interictal continuum
2. Planned withdrawal of life sustaining therapy.

Study Design

Enrollment

240 participants

Anticipated

Interventions and Outcome Measures

Arms

Traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, or cardiac arrest.

Adult patients with acute neurological injury with Disorders of Consciousness (Traumatic brain injury, intracerebral hemorrhage, subarachnoid hemorrhage, or cardiac arrest).

Primary outcome measure

  • Number of assessments that are successfully obtained [ Time Frame: Day 14 (or hospital discharge if that occurs earlier than 14 days) ]

Central Contacts and Locations

Central contacts

Jan Claassen, MD

212-305-7236JC1439@cumc.columbia.edu

Angela Velazquez, MD

212-305-6071Agv2113@cumc.columbia.edu

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Jan Claassen, MD

212-305-7236Jc1439@cumc.columbia.edu

More Information

Sponsor

Columbia University

Last update posted

Nov 4, 2026

Last verified

Oct, 2026

Keywords

  • Disorders of consciousness (DoC)
  • Cognitive Motor Dissociation (CMD)

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-05. This information was provided to ClinicalTrials.gov by Columbia University on 2026-11-04. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.