Recruiting

Observational Study

Sponsor:

Michigan State University

Code:

NCT07924839

Conditions

Cardiovascular (CV) Risk

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Interventions

Air filtration systems without filters (sham)

Study Details

Brief summary:

Obesity and exposure to fine particulate matter (particles of aerodynamic diameter less than 2.5 µm, PM2.5) air pollution are established risk factors for cardiovascular (CV) morbidity and mortality. This proposed pilot project seeks to assess interactions between PM2.5 exposure, obesity, CV health, and dietary antioxidant in subjects with obesity.

Conditions

Cardiovascular (CV) Risk

Study ID

NCT07924839

Start date

Jun 18, 2025

Status verified date

Mar, 2026

Completion date

Jan 31, 2027

Anticipated

Primary completion date

Oct 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • ≥21 years old
  • diagnosis of hypertension (BP ≥140/90 mm Hg)
  • obesity (BMI>30)

Exclusion Criteria:

  • any CV event (myocardial infarction, stroke, heart failure) in the past 3 months
  • unstable CV condition (class 3-4 angina or heart failure) or any medical condition that would place the subject at risk from participation or jeopardize study integrity (per investigators)
  • expected overnight travel outside their home during the 9-week study period
  • unable to comprehend/sign informed consent
  • lung disease requiring oxygen
  • cancer receiving active treatment or chemotherapy
  • CPAP use for sleep apnea
  • CV medication change in the prior month

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

sham comparator: Arm 1

Participants are exposed to unfiltered air (sham) via air filtration systems in the bedroom and main living space of each residence.

active comparator: Arm 2

Participants were exposed to high-efficiency (HEPA) filtered air via air filtration systems in the bedroom and main living space of each residence.

Interventions

Air filtration systems without filters (sham)

Subjects were exposed to high-efficiency filtered air.

Primary outcome measure

  • Brachial blood pressure [ Time Frame: Daily for 28 days, between 8-10 AM, starting 24 hours after air filtration systems are placed ]

Central Contacts and Locations

Locations

Michigan State University

Recruiting

East Lansing, Michigan, United States, 48824

Contacts

Study coordinator

517-884-4068klaverza@msu.edu

More Information

Sponsor

Michigan State University

Last update posted

Nov 9, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-10. This information was provided to ClinicalTrials.gov by Michigan State University on 2026-11-09. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.