Recruiting

Observational Study

Sponsor:

Boston University Charles River Campus

Code:

NCT07926347

Conditions

Aphasia

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Constant Therapy program

Study Details

Brief summary:

The objective of this study is to apply state-of-the art brain imaging approaches to evaluate new hypotheses about the contributions of core linguistic vs. domain-general executive systems to language processing and recovery in patients with varying degrees of linguistic impairment. Specifically, the investigators will first characterize the degree to which standard language assessments tax the domain-general Multiple Demand (MD) network (Aim 1). And then systematically investigate the causal contributions of the language and the MD networks to language processing and aphasia recovery in patients of varying severity (Aims 2 and 3).

Conditions

Aphasia

Study ID

NCT07926347

Start date

Dec, 2026

Status verified date

Nov, 2026

Completion date

Jul, 2032

Anticipated

Primary completion date

Jul, 2031

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • at least 12 weeks post-stroke at time of study enrolment
  • medically and neurologically stable (no active seizures for 6 months) and at least wheelchair ambulatory
  • premorbid fluency in English
  • a family member or caregiver available to assist in study setup and in communicating with study staff

Exclusion Criteria:

  • a major, active neurological condition other than stroke, as determined by medical record review
  • history of cognitive impairment unrelated to stroke, such as dementia
  • history of symptomatic stroke prior to index stroke
  • severe uncorrected vision and/or hearing problems likely to impact study participation
  • comorbid learning or language disorder diagnosed prior to stroke or as a child

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Immediate treatment

Participants randomized to this arm will receive the intervention immediately after baseline behavioral and neural procedures.

active comparator: Delayed treatment

Participants randomized to this arm will be put on a waitlist for 5 weeks and will then receive the intervention.

Interventions

Constant Therapy program

The Constant Therapy program includes includes 91 therapy exercise programs and participants can practice any of the exercises in the program for 50 hours (60 minutes a day, 5 days a week for 10 weeks).

Primary outcome measure

  • Change in the Western Aphasia Battery Revised Aphasia Quotient [ Time Frame: Baseline, immediately after the 10-week intervention ]

Central Contacts and Locations

Central contacts

Swathi Kiran, PhD

617-358-5478kirans@bu.edu

Locations

Center for Brain Recovery, BU Charles River Campus

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Swathi Kiran, PhD

617-358-5478brainrec@bu.edu

More Information

Sponsor

Boston University Charles River Campus

Last update posted

Nov 10, 2026

Last verified

Nov, 2026

Keywords

  • Constant Therapy program
  • Psychotherapy
  • Lifestyle counseling
  • Lesion load

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-11. This information was provided to ClinicalTrials.gov by Boston University Charles River Campus on 2026-11-10. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.