Recruiting

Vinegar

Sponsor:

Arizona State University

Code:

NCT07927296

Conditions

Heartburn

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Vinegar

vinegar pill

Study Details

Brief summary:

In this study, a popular home remedy, vinegar, will be tested for its efficacy to relieve the discomfort of heartburn possibly by inducing the esophageal clearing mechanisms. We plan to recruit 22 individuals who report regular heartburn, but not diagnosed with erosive reflux disease, for this randomized crossover trial. Enrolled participants will identify foods that consistently cause their heartburn, and two of these foods will be prepared and consumed during their visits. Participants will arrive at the testing center on two occasions following a 4-h fast (no food or beverage except water) and consume the targeted foods in a 10-minute period. On one visit liquid vinegar will be ingested with the meal, and on the other visit (order of visits will be randomly determined) a vinegar tablet (control) will be ingested with the meal. Starting prior to food ingestion and for 2 hours post meal, symptoms will be assessed at 10-to-15-minute intervals by the participant using a validated heartburn severity scale.

Conditions

Heartburn

Study ID

NCT07927296

Start date

Nov 16, 2026

Status verified date

Nov, 2026

Completion date

May 15, 2027

Anticipated

Primary completion date

May 15, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • report heartburn symptoms two or more times a week for several weeks or months
  • Any over the counter PPI use (proton-pump inhibitors such as Prilosec, Nexium, Prevacid) will need to be restricted for one month.

Exclusion Criteria:

  • Drug use (prescription, over-the-counter, or otherwise) known to affect the stomach and digestive processes, including GLP-1 RA or GLP/GIP medications
  • Medical conditions that impact normal functioning of the gastrointestinal tract (e.g., Crohn's disease, Celiac disease, short bowel syndrome, ostomy, lactose intolerance, hernia , SIBO, H. Pylori positive hasn't been cleared etc.).
  • Excess alcohol use (>2 servings daily)

Study Design

Enrollment

22 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Vinegar drink

2 tablespoons apple cider vinegar

placebo comparator: Placebo

Vinegar tablet

Interventions

Vinegar

2 Tablespoons

vinegar pill

Tablet

Primary outcome measure

  • heartburn symptoms [ Time Frame: measured premeal and at 15 to 30 minute intervals during the 2-h postprandial period ]

Central Contacts and Locations

Central contacts

Carol Johnston, PhD

6024963463carol.johnston@asu.edu

Locations

Arizona Biomedical Collaborative

Recruiting

Phoenix, Arizona, United States, 85004

Contacts

Carol Johnston, PhD

6024962539carol.johnston@asu.edu

More Information

Sponsor

Arizona State University

Last update posted

Nov 10, 2026

Last verified

Nov, 2026

Keywords

  • vinegar
  • heartburn

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-11. This information was provided to ClinicalTrials.gov by Arizona State University on 2026-11-10. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.