Recruiting

Blood Flow Restriction

Sponsor:

University of British Columbia

Code:

NCT07928531

Conditions

Type 2 Diabetes

Eligibility Criteria

Sex: All

Age: 19 - 64

Healthy Volunteers: Not accepted

Interventions

Exercise with BFR

Exercise

Study Details

Brief summary:

To conduct a randomized control trial to determine the impact of acute blood flow restriction treadmill walking on immune cell counts, function, and phenotype in adults living with type 2 diabetes.

Conditions

Type 2 Diabetes

Study ID

NCT07928531

Start date

Feb 11, 2026

Status verified date

Nov, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 64

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Aged 19-64 years
  • Diagnosed with type 2 diabetes with current HbA1c 5.7-9.0%
  • Completing <150 minutes of moderate-vigorous physical activity per week.

Exclusion Criteria:

  • Chronic musculoskeletal condition or recent (within 2 years) cardiovascular event preventing participation in exercise.
  • Unstable type 2 diabetes medication of the last 3 months
  • Absolute contraindications to BFR (i.e., peripheral vascular disease)
  • A self-reported diagnosis of low iron concentrations, anemia, or being treated for these conditions
  • A diagnosis of any red blood cell-altering condition (i.e., sickle cell anemia, poikilocytosis)
  • Currently living with any cardiovascular disease, which would impact the ability to participate in exercise safely
  • Currently prescribed any medication which would impact the ability to use a heart rate monitor to accurately track intensity

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Treadmill walking with blood flow restriction

Treadmill walking with blood flow restriction.

active comparator: Treadmill Walking

Treadmill walking.

Interventions

Exercise with BFR

Participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve. The cuffs will be inflated based on each participants individualized limb occlusion pressure (LOP). The cuffs will remain inflated for the entire session but will deflate for 1 minute every 10 minutes based on safety recommendations. The percentage of LOP will 60%.

Exercise

Participants will complete 32 minutes of treadmill walking at a speed and grade that elicit 40-50% heart rate reserve.

Primary outcome measure

  • Change in white blood cell count before, during, and after exercise. [ Time Frame: Pre-exercise, during 32 minute of exercise, immediately post-exercise ]

Central Contacts and Locations

Central contacts

Jonathan P Little, PhD

250-807-9876jonathan.little@ubc.ca

Locations

University of British Columbia Okanagan

Recruiting

Kelowna, British Columbia, Canada, V1V 1V7

Contacts

Jonathan P Little, PhD

250-807-9876jonathan.little@ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Nov 10, 2026

Last verified

Nov, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-11. This information was provided to ClinicalTrials.gov by University of British Columbia on 2026-11-10. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.