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Roche Clinical Trials

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A Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Muscular Atrophy Who Experienced a Plateau or Decline in Function After Gene Therapy

for
Muscular Atrophy, Spinal
Location: Philadelphia PA, Gainesville FL, Atlanta GA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 0 - 2

Code: NCT05861999

Phase 4, Recruiting
FeaturedActive & Responsive

A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts

for
Influenza
Location: Miami FL, Smithfield PA, Middleburg Heights OH,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 0 - 11

Code: NCT06094010

Phase 3, Recruiting
FeaturedActive & Responsive

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

for
Metastatic Colorectal Cancer
Location: Port Jefferson Station NY, New Haven CT,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT04929223

Phase 1, Recruiting
FeaturedActive & Responsive

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

for
Metastatic Breast Cancer
Location: Durham NC, Columbus OH, Chattanooga TN, Nashville TN,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT03424005

Phase 1, Phase 2, Recruiting
FeaturedActive & Responsive

A Study to Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, and Pharmacodynamics of Satralizumab in Pediatric Patients With Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder (NMOSD)

for
Neuromyelitis Optica Spectrum Disorder, NMOSD
Location: Denver CO
Sponsor: Hoffmann-La Roche

Sex: All

Age: 2 - 11

Code: NCT05199688

Phase 3, Recruiting

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A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for
Moderately to Severely Active Crohns Disease
Location: Boston MA, Providence RI, North Massapequa NY,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 16 - 70+

Code: NCT06819878

Phase 3, Recruiting
Featured

A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma

for
Mature B-Cell Non-Hodgkin Lymphoma
Location: Boston MA, New York NY, Baltimore MD, Cincinnati OH,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 0 - 30

Code: NCT05533775

Phase 1, Phase 2, Recruiting
Featured

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer,
Location: Boston MA, Philadelphia PA, Charlotte NC, Germantown TN,
Sponsor: Hoffmann-La Roche

Sex: Female

Age: 18+

Code: NCT04802759

Phase 1, Phase 2, Recruiting
Featured

A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma

for
Lymphoma
Location: New Haven CT, Stony Brook NY, New Brunswick NJ,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06084936

Phase 3, Recruiting
Featured

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Persons With Severe or Moderate Hemophilia A

for
Hemophilia A
Location: Hamilton, Indianapolis IN, Iowa City IA, Vancouver,
Sponsor: Hoffmann-La Roche

Sex: Male

Age: 2 - 59

Code: NCT05987449

Phase 1, Phase 2, Recruiting
Featured

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia

for
Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Location: Columbus OH, Rochester MN, Salt Lake City UT
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT05091424

Phase 1, Recruiting
Featured

A Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatric Participants With Spinal Muscular Atrophy After Gene Therapy

for
Muscular Atrophy, Spinal
Location: New York NY, Philadelphia PA, Gainesville FL,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 0 - 2

Code: NCT05861986

Recruiting
Featured

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for
Huntington Disease
Location: Boston MA, Philadelphia PA, Pittsburgh PA, Columbus OH,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 25 - 65

Code: NCT06826612

Phase 1, Phase 2, Recruiting
Featured

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

for
Metastatic Breast Cancer
Location: Moncton, Boston MA, Quebec, Montreal, Hyattsville MD,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT05894239

Phase 3, Recruiting
Featured

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

for
Non-Small Cell Lung Cancer
Location: New Haven CT, Mineola NY, The Bronx NY, New York NY,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT05789082

Phase 1, Phase 2, Recruiting
Featured

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for
Moderately to Severely Active Crohns Disease
Location: Providence RI, North Worcester MA, Lebanon NH,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 16 - 70+

Code: NCT06819891

Phase 3, Recruiting
Featured

A Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With Atopic Dermatitis

for
Atopic Dermatitis
Location: Minneapolis MN
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT07223697

Phase 2, Recruiting
Featured

An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis

for
Active Ulcerative Colitis
Location: Miami FL, Chula Vista CA
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18 - 60

Code: NCT07665723

Phase 1, Recruiting
Featured

Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma

for
Multiple Myeloma
Location: New Haven CT, Washington D.C. DC, Winston-Salem NC,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT07555938

Phase 3, Recruiting
Featured

A Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophilia A

for
Hemophilia A
Location: Miami FL, Tampa FL, London, Ann Arbor MI,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 12+

Code: NCT07416604

Phase 3, Recruiting