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Paid Clinical Trials Irvine

Discover 3,580 paid clinical trials in Irvine, California. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for
Anatomic Stage III Breast Cancer AJCC v8,
Location: Newport Beach CA, Los Angeles CA, Houston TX,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 12+

Code: NCT05372640

Phase1, Recruiting

A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma

for
Melanoma (Skin Cancer), Melanoma Stage IIIB-IV,
Location: Newport Beach CA, Stanford CA, San Francisco CA,
Sponsor: Linnaeus Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06624644

Phase2, Phase3, Recruiting

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

for
Breast Neoplasms
Location: Newport Beach CA, Cerritos CA, Los Angeles CA,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06926868

Phase2, Phase3, Recruiting

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for
Metastatic Clear Cell Renal Cell Carcinoma,
Location: Newport Beach CA, Huntington Beach CA, Buena Park CA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT04510597

Phase3, Recruiting

A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis

for
Breast Carcinoma
Location: Newport Beach CA, Los Angeles CA
Sponsor: University of Southern California

Sex: Female

Age: 18+

Code: NCT06336928

Recruiting

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Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

for
Metastatic Nasopharyngeal Carcinoma,
Location: Newport Beach CA, Los Angeles CA, Fresno CA, Modesto CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06029270

Phase2, Recruiting

A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near and Intermediate Vision in Pseudophakic Presbyopic Subjects

for
Presbyopia, Pseudophakia
Location: Orange CA, Laguna Hills CA, Salt Lake City UT,
Sponsor: ReVision Optics, Inc.

Sex: All

Age: 50+

Code: NCT02668523

Phase3, Recruiting

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

for
Prostate Cancer
Location: Orange CA, Santa Monica CA, Scottsdale AZ, Aurora CO,
Sponsor: Novartis Pharmaceuticals

Sex: Male

Age: 18 - 70+

Code: NCT05803941

Recruiting

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

for
Melanoma
Location: Orange CA, Fullerton CA, Los Alamitos CA, Redlands CA,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06246916

Phase3, Recruiting

Molecular Genetics Studies of Cancer Patients and Their Relatives

for
Malignant Neoplasm
Location: Orange CA, Laguna Hills CA, Fullerton CA, Duarte CA,
Sponsor: City of Hope Medical Center

Sex: All

Age: 0+

Code: NCT04185935

Recruiting

Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Acute Femoropopliteal DVT

for
Thrombosis, Deep Vein, Iliofemoral; Thrombosis
Location: Orange CA, Houma LA, Atlanta GA, Pittsburgh PA,
Sponsor: Mercator MedSystems, Inc.

Sex: All

Age: 18 - 70+

Code: NCT04862468

Phase2, Recruiting

A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.

for
Non Small Cell Lung Cancer (Squamous or Non Squamous),
Location: Orange CA, Glendale CA, Albuquerque NM, Pueblo CO,
Sponsor: Eikon Therapeutics

Sex: All

Age: 18+

Code: NCT07365319

Phase2, Phase3, Recruiting

A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Isolated Microvascular Inflammation

for
Microvascular Inflammation
Location: Orange CA, Los Angeles CA, Loma Linda CA,
Sponsor: Biogen

Sex: All

Age: 18 - 70+

Code: NCT07219043

Phase2, Recruiting

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

for
Non-Small-Cell Lung Cancer,
Location: Orange CA, Fullerton CA, Los Angeles CA,
Sponsor: ArriVent BioPharma, Inc.

Sex: All

Age: 18+

Code: NCT07185997

Phase3, Recruiting

Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

for
AMI Cardiogenic Shock
Location: Orange CA, Torrance CA, Albuquerque NM, Portland OR,
Sponsor: Abiomed Inc.

Sex: All

Age: 18+

Code: NCT06964685

Recruiting

Machine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction

for
Central Line Associated Blood Stream Infections (CLABSI)
Location: Orange CA, Mission Viejo CA, Fullerton CA, Burbank CA,
Sponsor: Swedish Medical Center

Sex: All

Age: 18+

Code: NCT07108660

Recruiting

Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for
NSCLC
Location: Orange CA, Los Angeles CA, Davis CA, Seattle WA,
Sponsor: Lung Cancer Mutation Consortium

Sex: All

Age: 0+

Code: NCT04712877

Recruiting

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

for
Pancreatic Acinar Cell Carcinoma,
Location: Orange CA, Las Vegas NV, Kingman AZ, Modesto CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT04858334

Phase2, Recruiting

Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

for
Atopic Dermatitis
Location: Newport Beach CA, Las Vegas NV, Phoenix AZ, Fremont CA,
Sponsor: Galderma R&D

Sex: All

Age: 12+

Code: NCT06988605

Recruiting
New

Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation

for
Atrial Fibrillation (AF)
Location: Newport Beach CA, Pasadena CA, Northridge CA,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07626411

Phase3, Recruiting