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Paid Clinical Trials Irvine

Discover 3,581 paid clinical trials in Irvine, California. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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FeaturedActive & Responsive

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

for
Metastatic Breast Cancer
Location: Irvine CA, Duarte CA, Los Angeles CA, La Jolla CA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT03424005

Phase1, Phase2, Recruiting
FeaturedActive & Responsive

Secretome Treatment for Facial Rejuvenation

for
Facial Aging, Rejuvenation, Stem Cell, Stem Cell Banking
Location: Newport Beach CA
Sponsor: Acorn Biolabs Inc.

Sex: All

Age: 30 - 70

Code: NCT07227883

Early_phase1, Recruiting
FeaturedActive & Responsive

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

for
Moderately to Severely Active Ulcerative Colitis
Location: Newport Beach CA, Garden Grove CA, Los Angeles CA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 16 - 70+

Code: NCT06588855

Phase3, Recruiting
FeaturedActive & Responsive

A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

for
Rheumatoid Arthritis
Location: Huntington Beach CA, Torrance CA, Upland CA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06972446

Phase2, Recruiting
FeaturedActive & Responsive

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for
Moderately to Severely Active Crohns Disease
Location: Garden Grove CA, Los Alamitos CA, Inglewood CA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 16 - 70+

Code: NCT06819878

Phase3, Recruiting

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FeaturedActive & Responsive

A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

for
Metastatic Colorectal Cancer
Location: Duarte CA, Los Angeles CA, Phoenix AZ, Lone Tree CO,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT04929223

Phase1, Recruiting
FeaturedActive & Responsive

A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251

for
Geographic Atrophy
Location: Beverly Hills CA, San Francisco CA, Sacramento CA,
Sponsor: Genentech, Inc.

Sex: All

Age: 50+

Code: NCT05626114

Phase2, Recruiting
Featured

A Study to Assess the Safety and Effects of ABBV-1758 Following Subcutaneous or Intravenous Injections in Participants With Alzheimer's Disease

for
Alzheimer's Disease
Location: Irvine CA, Boulder CO, Dallas TX, Cordova TN,
Sponsor: AbbVie

Sex: All

Age: 50 - 70+

Code: NCT07599670

Phase1, Phase2, Recruiting
Featured

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

for
Alzheimers Disease
Location: Irvine CA, Santa Ana CA, Long Beach CA, Riverside CA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 50 - 70+

Code: NCT07177352

Phase3, Recruiting
Featured

A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

for
Alzheimers Disease
Location: Irvine CA, Santa Ana CA, Los Angeles CA, Sun City AZ,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 50 - 70+

Code: NCT07169578

Phase3, Recruiting
Featured

A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events

for
Atherosclerosis
Location: Irvine CA, Beverly Hills CA, West Hills CA,
Sponsor: Genentech, Inc.

Sex: All

Age: 18+

Code: NCT07448038

Phase2, Recruiting
Featured

A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
Location: Irvine CA, Orange CA, Newport Beach CA, Los Angeles CA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06793215

Phase3, Recruiting
FeaturedNew

Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

for
Obesity, Overweight
Location: Tustin CA, Santa Ana CA, Spring Valley CA,
Sponsor: AbbVie

Sex: All

Age: 18 - 70+

Code: NCT07752979

Phase2, Recruiting
Featured

A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)

for
Systemic Lupus Erythematosus, Rheumatoid Arthritis
Location: Tustin CA, Red Oak TX, Orland Park IL, Anniston AL,
Sponsor: AbbVie

Sex: All

Age: 18 - 70+

Code: NCT07607964

Phase1, Recruiting
Featured

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

for
Obesity or Overweight
Location: Irvine CA, San Diego CA, Walnut Creek CA, Tucson AZ,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT07351045

Phase3, Recruiting
Featured

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

for
Neovascular Age-related Macular Degeneration
Location: Santa Ana CA, Newport Beach CA, Huntington Beach CA,
Sponsor: AbbVie

Sex: All

Age: 50+

Code: NCT07007065

Phase3, Recruiting
Featured

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer,
Location: Irvine CA, Santa Monica CA, Duarte CA, Stanford CA,
Sponsor: Hoffmann-La Roche

Sex: Female

Age: 18+

Code: NCT04802759

Phase1, Phase2, Recruiting
Featured

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for
Non Small Cell Lung Cancer
Location: Irvine CA, Huntington Beach CA, Duarte CA, Lancaster CA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT04928846

Phase3, Recruiting
Featured

A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

for
Metastatic Breast Cancer
Location: Irvine CA, Corona CA, Duarte CA, Los Angeles CA,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT05894239

Phase3, Recruiting
Featured

A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

for
Non-Small Cell Lung Cancer
Location: Irvine CA, Duarte CA, La Jolla CA, Vancouver WA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT07155187

Phase2, Phase3, Recruiting