Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
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CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations
Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System
Comparing the Radiopharmaceutical Drug, [177Lu]Lu-DOTATATE, to Standard of Care Treatment for Patients With Meningioma That Has Come Back After Prior Treatment
Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment
Inotuzumab Ozogamicin and Blinatumomab With or Without Ponatinib in Treating Patients With Newly Diagnosed, Recurrent, or Refractory CD22-Positive B-Lineage Acute Lymphoblastic Leukemia
San Diego is renowned in the world of medical research, with an expansive healthcare infrastructure and world-class medical research institutions. Major organizations such as UC San Diego Health, Scripps Research, and the Sanford Burnham Prebys Medical Discovery Institute are at the forefront of pioneering studies in various medical fields. These institutions leverage San Diego's innovative biotech landscape, making it a key destination for innovative clinical research.
Why choose San Diego for clinical trials?
San Diego offers distinct advantages for those participating in clinical trials. The city's thriving biotech industry and diverse population create an ideal environment for high-quality research with broad applicability.
By choosing to participate in a clinical trial in San Diego, you contribute to important breakthroughs in healthcare while benefiting from a well-established, cutting-edge research ecosystem that supports participants with exceptional care and resources.
Common conditions studied in San Diego
San Diego stands out as a significant center for clinical research, with a focus on several key medical conditions and diseases.
Diabetes and metabolic disorders
San Diego is recognized for its contributions to diabetes research, particularly in advancing treatments for Type 1 and Type 2 diabetes. Clinical trials often explore new insulin formulations, advanced glucose monitoring technologies, and innovative approaches like gene editing or cellular therapies aimed at restoring insulin production.
Researchers are also investigating lifestyle interventions and medications to better manage blood glucose levels and improve overall patient health.
Neurological disorders
In the realm of neurological disorders, San Diego is known for its advanced research into Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Clinical trials often focus on new drug candidates designed to slow disease progression or improve symptoms, as well as experimental gene therapies aimed at addressing the underlying genetic causes of these disorders.
The city also benefits from a robust network of research facilities that employ cutting-edge imaging technologies to better understand disease mechanisms and assess treatment efficacy.
Cancer
San Diego is renowned for its cancer research, driven by institutions such as UC San Diego Health and Moores Cancer Center. Oncology clinical trials here explore a wide array of cancer types, including breast cancer, prostate cancer, melanoma, and pancreatic cancer.
The city is at the forefront of innovative oncology treatment approaches such as immunotherapy, which harnesses the body's immune system to target cancer cells, and targeted therapies that aim to disrupt specific cancer cell pathways. Researchers in San Diego are also investigating combination therapies and personalized medicine strategies to improve patient outcomes and reduce side effects.
Interested in learning more about how clinical trials for cancer work? Explore our guide to better understand oncology clinical trials and how they contribute to advancing cancer treatments.
Infectious diseases
The city is also a hub for research into infectious diseases, including HIV/AIDS, hepatitis C, and emerging viral infections. Institutions such as Scripps Research and UC San Diego are actively involved in developing new vaccines and antiviral drugs.
Trials in this area often focus on improving treatment regimens, enhancing vaccine efficacy, and addressing resistance to existing therapies. San Diego’s strategic location and collaborations with international research networks bolster its efforts in combating global health threats.
Autoimmune diseases
San Diego’s research on autoimmune diseases includes trials focused on rheumatoid arthritis, lupus, hidradenitis suppurativa (HS) and other conditions where the immune system attacks the body’s own tissues. Studies frequently investigate novel biologic drugs that target specific immune system components to reduce inflammation and prevent joint damage.
Additionally, researchers are exploring new approaches to modulate the immune response and improve long-term management of these chronic conditions.
Local regulations and guidelines
In San Diego, clinical trials are governed by a comprehensive framework of federal, state, and local regulations to ensure ethical and scientific integrity. At the federal level, trials must comply with U.S. Food and Drug Administration (FDA) guidelines and the Office for Human Research Protections (OHRP) standards, which include ethical considerations and informed consent. Local Institutional Review Boards (IRBs) at major institutions must oversee the ethical aspects of research and protect participant welfare.
Additionally, California-specific regulations enforced by the California Department of Public Health (CDPH) and privacy laws such as the California Consumer Privacy Act (CCPA) further ensure that trials adhere to state standards. Researchers must also follow Good Clinical Practice (GCP) guidelines and maintain stringent data privacy protections under laws like HIPAA.
Benefits of participating in clinical trials
Joining a clinical trial provides an exclusive opportunity to access advanced treatments and therapies before they become available to the general public. Participants receive exceptional care from leading healthcare professionals, who deliver personalized attention and comprehensive monitoring throughout the study.
Volunteering in clinical trials is vital for pushing forward medical research, frequently resulting in significant advancements in both treatment and prevention. By participating, individuals not only gain early access to innovative medical solutions but also contribute substantially to the expansion of scientific knowledge, enhancing healthcare outcomes for future patients.
How to enroll in a clinical trial in San Diego
Enrolling in a clinical trial through our platform is a straightforward and user-friendly process. Here's how to get started:
- Identify your trial: Use our intuitive search bar or filter options to locate clinical trials specific to requirements. This first step simplifies the process of finding relevant research studies tailored to your needs.
- Select your preferred location: To find trials conveniently located near you, simply input your preferred location into the dedicated filter bar on the left-hand side of the page.
- Explore study details: For in-depth information about each study, simply click the “Learn More” button. This will provide you with comprehensive details about the trial, including objectives, procedures, and eligibility criteria.
- Complete the health profile: After clicking on the “Get started” button you will be taken to our efficient 5-step application process to provide important health information. This helps us match you with the clinical trial that best fits your needs.
- Submit the application: After completing the application, send it in. A clinical trial coordinator will review it and contact you regarding the possibility of participation.