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Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

for
Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18 - 70

Code: NCT04708054

Phase2, Phase3, Recruiting

Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant

for
Acute Myeloid Leukemia, Graft Versus Host Disease,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06996119

Phase1, Recruiting

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06815003

Phase2, Recruiting

A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia
Location: Buffalo NY, Tampa FL, Columbus OH, Grand Rapids MI,
Sponsor: Debiopharm International SA

Sex: All

Age: 18+

Code: NCT06969430

Phase1, Phase2, Recruiting

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

for
High-risk Myelodysplastic Syndrome,
Location: Boston MA, New York NY, Philadelphia PA, Tampa FL,
Sponsor: Crossbow Therapeutics, Inc.

Sex: All

Age: 12+

Code: NCT06994676

Phase1, Recruiting

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MT2025-35 Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced Intensity Conditioning Treosulfan and Fludarabine, With Post-Transplant Cytoxan (PTCy) for the Treatment of Hematological Diseases

for
AML, MDS, Acute Leukemia, Acute Myeloid Leukemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 2 - 70+

Code: NCT07493538

Phase2, Recruiting

Evaluation of Two Dose Levels of Quizartinib as Maintenance in FLT3-ITD (+) Acute Myeloid Leukemia Patients in Complete Remission

for
Acute Myeloid Leukemia, Leukemia
Location: Easton PA, Houston TX
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06824168

Phase2, Recruiting

Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

for
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome,
Location: Portland OR
Sponsor: Jennifer Saultz

Sex: All

Age: 18+

Code: NCT03874052

Phase1, Recruiting

Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)

for
Acute Myeloid Leukemia
Location: Baltimore MD, Pittsburgh PA, Orlando FL, Columbus OH,
Sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland

Sex: All

Age: 18+

Code: NCT07223814

Phase3, Recruiting

A Study of Natural Killer Cells in Combination With Atezolizumab in People With Acute Myelogenous Leukemia

for
Acute Myeloid Leukemia Refractory,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18 - 70

Code: NCT07011004

Phase1, Recruiting

Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant

for
Myeloid Malignancy, Acute Myeloid Leukemia
Location: Cleveland OH
Sponsor: Benjamin Tomlinson

Sex: All

Age: 18+

Code: NCT06129734

Phase1, Phase2, Recruiting

Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia

for
Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT06710418

Recruiting

HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant

for
Juvenile Myelomonocytic Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 0 - 70+

Code: NCT03326921

Phase1, Recruiting

Home Blood Transfusions

for
Hematologic Malignancy, Myelodysplastic Syndromes,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT07121140

Recruiting

Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer

for
Acute Leukemia of Ambiguous Lineage, Acute Myeloid Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT07046078

Phase2, Recruiting

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

for
Germline Mutation, Myelodysplastic Syndromes,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 0 - 70+

Code: NCT07019155

Recruiting

Dose Escalation and Expansion of Ziftomenib in Combination With Quizartinib in Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06769490

Phase1, Recruiting

Safety of MT-401-OTS in Patients With Relapsed AML or MDS

for
Acute Myeloid Leukemia, in Relapse, MDS
Location: Tampa FL, Kansas City KS, Duarte CA
Sponsor: Marker Therapeutics, Inc.

Sex: All

Age: 65+

Code: NCT06552416

Phase1, Recruiting

ONC-LEUK-2406: The Impact of Systematic Financial Navigation in Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Winston-Salem NC, Charlotte NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18 - 64

Code: NCT06945042

Recruiting

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

for
Acute Myeloid Leukemia, Acute Undifferentiated Leukemia,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT06928662

Phase1, Phase2, Recruiting