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A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid Leukemia

for
Advanced Chronic Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06401603

Phase1, Recruiting

Niclosamide in Pediatric Patients With Relapsed and Refractory AML

for
Acute Myeloid Leukemia (AML)
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 2 - 25

Code: NCT05188170

Phase1, Recruiting

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Halifax, Bangor ME, Scarborough ME, Boston MA,
Sponsor: PedAL BCU, LLC

Sex: All

Age: 0 - 22

Code: NCT04726241

Phase1, Phase2, Recruiting

A Phase 1 Study of STX-0712 in Patients With Advanced Hematological Malignancies (CMML and AML)

for
Chronic Myelomonocytic Leukemia,
Location: Boston MA, Tampa FL, Rochester MN, Houston TX,
Sponsor: Solu Therapeutics, Inc

Sex: All

Age: 18+

Code: NCT06950034

Phase1, Recruiting

Evaluation of Tranexamic Acid in Myelodysplastic Syndromes and Acute Myeloid Leukemia

for
Myelodysplastic Syndromes, Acute Myeloid Leukemia,
Location: Winnipeg
Sponsor: University of Manitoba

Sex: All

Age: 18+

Code: NCT06599762

Phase2, Recruiting

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Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1

for
Relapsed/Refractory Acute Myeloid Leukemia
Location: New Haven CT, Hackensack NJ, Philadelphia PA,
Sponsor: SystImmune Inc.

Sex: All

Age: 18+

Code: NCT06714591

Phase1, Recruiting

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for
Acute Myeloid Leukemia
Location: Halifax, Bangor ME, Scarborough ME, Boston MA,
Sponsor: Children's Oncology Group

Sex: All

Age: 0 - 21

Code: NCT04293562

Phase3, Recruiting

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome,
Location: Boston MA, New Haven CT, Commack NY, Uniondale NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06484062

Phase1, Recruiting

APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML

for
Acute Myeloid Leukemia (AML)
Location: Miami FL, Canton OH, Cincinnati, OH, Fairway KS,
Sponsor: Aptevo Therapeutics

Sex: All

Age: 18+

Code: NCT06634394

Phase1, Recruiting

CLAG-GO for Patients With Persistent, Relapsed or Refractory AML

for
Acute Myeloid Leukemia, Adult, Acute Myeloid Leukemia Recurrent,
Location: Baltimore MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18+

Code: NCT04050280

Phase2, Recruiting

CER-1236 in Patients With Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Myelofibrosis (MF)

for
AML, Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
Location: Nashville TN, Houston TX, Denver CO, Sacramento CA
Sponsor: CERo Therapeutics Holdings, Inc.

Sex: All

Age: 18 - 70+

Code: NCT06834282

Phase1, Recruiting

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia in Remission,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT03670966

Phase1, Phase2, Recruiting

Trial With Azacitidine in Newly Diagnosed Acute Myelogenous Leukemia (AML) Veterans Administration (VA) Elderly Patients Not Eligible for Standard Induction Therapy

for
Acute Myeloid Leukemia, Elderly
Location: Kansas City MO
Sponsor: Kansas City Veteran Affairs Medical Center

Sex: All

Age: 60+

Code: NCT00728520

Phase2, Recruiting

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

for
Hematologic Malignancy, AML, ALL, BPDCN, MDS,
Location: New York NY, Washington DC, Ann Arbor MI, Cincinnati OH,
Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

Sex: All

Age: 1 - 21

Code: NCT05476770

Phase1, Recruiting

Cord Blood Transplant in Adults With Blood Cancers

for
Acute Myelogenous Leukemia (AML),
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 21 - 65

Code: NCT05884333

Phase2, Recruiting

Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AML

for
Leukemia, Myeloid, Acute
Location: Winston-Salem NC, Charlotte NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 18+

Code: NCT06580106

Recruiting

Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

for
AML, ALL, MDS, MPD Withou Myelofibrosis, NHL or HL,
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 0 - 21

Code: NCT04644016

Phase2, Recruiting

A Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML)

for
AML, Adult
Location: Winston-Salem NC, Charlotte NC, Houston TX, Seattle WA,
Sponsor: Ascentage Pharma Group Inc.

Sex: All

Age: 18 - 70+

Code: NCT04964518

Phase1, Phase2, Recruiting

Study of NEROFE, a Novel Hormone-Peptide in Adult Patients With Advanced MDS and AML

for
Advanced MDS, AML
Location: Miami FL
Sponsor: Immune System Key Ltd

Sex: All

Age: 18+

Code: NCT04365179

Phase1, Recruiting

A Phase I/II Dose Escalation and Expansion Study of BST-236 Plus Venetoclax in Patients With Unfit Newly Diagnosed AML

for
AML, Adult
Location: Charlottesville VA, Houston TX
Sponsor: BioSight Ltd.

Sex: All

Age: 18 - 70+

Code: NCT05503355

Phase1, Phase2, Recruiting