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A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

for
Leukemia, Myeloid, Acute
Location: Halifax, Boston MA, Lebanon NH, The Bronx NY,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06852222

Phase3, Recruiting

A Decisional Intervention for Older Adults With Acute Myeloid Leukemia and Their Caregivers

for
Oncology, Myeloid Leukemia, Acute, Cancer
Location: Rochester NY, Chapel Hill NC, Winston-Salem NC,
Sponsor: University of Rochester

Sex: All

Age: 60+

Code: NCT06697600

Recruiting

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for
AML (Acute Myelogenous Leukemia), Acute Lymphoid Leukemia (ALL),
Location: Boston MA, New York NY, Charlottesville VA,
Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All

Age: 18 - 66

Code: NCT06859424

Phase2, Recruiting

ICP-248 in Combination With Azacitidine for the Treatment in Patients With Myeloid Malignancies

for
Acute Myelogenous Leukemia, Myelodysplastic Syndromes (MDS)
Location: New Haven CT, New York NY, Chapel Hill NC, Tampa FL,
Sponsor: Beijing InnoCare Pharma Tech Co., Ltd.

Sex: All

Age: 18+

Code: NCT06656494

Phase1, Recruiting

Allo HSCT Using RIC and PTCy for Hematological Diseases

for
Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 70+

Code: NCT05805605

Phase2, Recruiting

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Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML

for
AML, Adult, MDS
Location: Boston MA, New York NY, Tampa FL, Cleveland OH,
Sponsor: Stelexis BioSciences

Sex: All

Age: 18+

Code: NCT06533761

Phase1, Recruiting

CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)

for
AML/MDS, B-ALL, T-ALL, BPDCN
Location: Memphis TN
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 21

Code: NCT04318678

Phase1, Recruiting

Study of APVO436 in Patients With AML or MDS

for
AML, MDS
Location: Miami FL, Gainesville FL, Greenville SC, Columbus OH,
Sponsor: Aptevo Research and Development LLC

Sex: All

Age: 18+

Code: NCT03647800

Phase1, Recruiting

CD33KO-HSPC Infusion Followed by CART-33 Infusion(s) for Refractory/Relapsed AML

for
Leukemia, Myeloid, Acute
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT05945849

Phase1, Recruiting

Molecular Imaging to Capture Disease Heterogeneity in Acute Myeloid Leukemia

for
Leukemia, Myeloid, Acute
Location: Hamilton
Sponsor: Hamilton Health Sciences Corporation

Sex: All

Age: 18+

Code: NCT02682732

Recruiting

Mitoxantrone for Venetoclax Resistant Acute Myeloid Leukemia

for
Leukemia, Myeloid Leukemia, Monocytic Leukemia
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT06429449

Phase1, Recruiting

Study of Oral PCLX-001 in R/R Acute Myeloid Leukemia

for
Relapsed Adult AML
Location: Houston TX
Sponsor: Pacylex Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06613217

Phase1, Recruiting

Efficacy Study of Inecalcitol With Decitabine in Acute Myeloid Leukemia Patients Unfit for Standard Chemotherapy

for
Acute Myelogenous Leukemia
Location: Durham NC, Augusta GA, Houston TX, Albuquerque NM,
Sponsor: Hybrigenics Corporation

Sex: All

Age: 65+

Code: NCT02802267

Phase2, Recruiting

Cladribine Plus Low Dose Cytarabine (LDAC) Alternating With Decitabine in Patients With Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

for
Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 60+

Code: NCT01515527

Phase2, Recruiting

A Phase I/II Study of Gilteritinib and Momelotinib for Patients With Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia

for
Myeloid Leukemia
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06235801

Phase1, Phase2, Recruiting

IS-free Treg HaploHCT

for
Stem Cell Transplant Complications, Graft Vs Host Disease,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18 - 70+

Code: NCT04678401

Phase1, Recruiting

eHealth Mindfulness-based Music Therapy Intervention for Patients Undergoing Stem Cell Transplantation

for
Stem Cell Transplantation, Myelodysplastic Syndromes,
Location: Miami FL
Sponsor: University of Miami

Sex: All

Age: 18+

Code: NCT07469592

Recruiting

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

for
Malignancy, Hematologic, Neoplasms, Hematologic,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT06904066

Phase1, Recruiting

ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

for
B-cell Acute Lymphoblastic Leukemia,
Location: Boston MA, Buffalo NY, Chicago IL
Sponsor: Marlise Luskin, MD

Sex: All

Age: 18+

Code: NCT03595917

Phase1, Recruiting

Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia

for
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03263572

Phase2, Recruiting