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BCL2i CLAG-M in R/R Acute Myeloid Leukemia

for
Relapsed or Refractory Acute Myeloid Leukemia (AML)
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18 - 70+

Code: NCT06660368

Phase2, Recruiting

Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy

for
Myelodysplastic Syndrome, Acute Myeloid Leukemia
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 0+

Code: NCT06510868

Recruiting

A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib

for
Acute Myeloid Leukemia
Location: Boston MA, New York NY, Baltimore MD, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12+

Code: NCT06284486

Phase1, Phase2, Recruiting

Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in AML and MDS

for
Whole Genome Sequencing, Acute Myeloid Leukemia,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT04986657

Recruiting

Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies

for
Hematologic Malignancy, Bone Marrow Transplant Rejection,
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT06398457

Early_phase1, Recruiting

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A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: New York NY, Kansas City KS, Duarte CA
Sponsor: GluBio Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06146257

Phase1, Recruiting

Study of Sapacitabine in Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS)

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: Houston TX
Sponsor: Cyclacel Pharmaceuticals, Inc.

Sex: All

Age: 18+

Code: NCT01211457

Phase1, Phase2, Recruiting

Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation

for
Relapsed or Refractory Acute Myeloid Leukemia (AML),
Location: Charleston SC, Houston TX, Dallas TX
Sponsor: Institut de Recherches Internationales Servier

Sex: All

Age: 18+

Code: NCT02074839

Phase1, Recruiting

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

for
Acute Leukemia, Acute Myeloid Leukemia,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 60

Code: NCT03314974

Phase2, Recruiting

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

for
B-Cell Non-Hodgkin Lymphoma,
Location: Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT03017820

Phase1, Recruiting

Fludarabine Phosphate, Cytarabine, Filgrastim-sndz, Gemtuzumab Ozogamicin, and Idarubicin Hydrochloride in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for
Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT00801489

Phase2, Recruiting

Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 60+

Code: NCT06195891

Phase1, Recruiting

JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation

for
MYELODYSPLASTIC SYNDROME; MDS, ACUTE MYELOID LEUKEMIA; AML
Location: Chicago IL, Salt Lake City UT, Seattle WA, Portland OR,
Sponsor: Jasper Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04429191

Phase1, Recruiting

Venetoclax With Combination Chemotherapy in Treating Patients With Newly Diagnosed or Relapsed or Refractory Acute Myeloid Leukemia

for
High Risk Myelodysplastic Syndrome,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT03214562

Phase1, Phase2, Recruiting

Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood Cancers

for
Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12+

Code: NCT03589729

Phase2, Recruiting

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

for
Acute Biphenotypic Leukemia, Acute Myeloid Leukemia,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT04797767

Phase1, Phase2, Recruiting

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70

Code: NCT06287944

Phase1, Recruiting

A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

for
Acute Myeloid Leukemia
Location: Cleveland OH, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05834244

Phase1, Recruiting

Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML

for
AML/MDS, Acute Myeloid Leukemia, Myelodysplastic Syndromes
Location: The Bronx NY, Houston TX
Sponsor: Montefiore Medical Center

Sex: All

Age: 18+

Code: NCT05986240

Phase1, Recruiting

Biomarkers in Patients With Anemia-Induced Thrombocytopenic Bleeding

for
Acute Leukemia, Acute Myeloid Leukemia (AML),
Location: Hamilton
Sponsor: Donald Arnold

Sex: All

Age: 18+

Code: NCT06947044

Recruiting