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Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

for
Acute Myeloid Leukemia, Acute Lymphoid Leukemia,
Location: Palo Alto CA
Sponsor: Stanford University

Sex: All

Age: 18 - 70

Code: NCT06551584

Phase1, Recruiting

Induction and Consolidation With Fludarabine, Cytarabine, Idarubicin, and Venetoclax for the Treatment of Acute Myeloid Leukemia

for
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18 - 65

Code: NCT07228273

Phase2, Recruiting

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

for
Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia,
Location: Durham NC, Decatur IL, Houston TX
Sponsor: AstraZeneca

Sex: All

Age: 16+

Code: NCT07155226

Phase1, Phase2, Recruiting

Genetically Engineered Cells (CD83 CAR T Cells) for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

for
Recurrent Acute Myeloid Leukemia,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT06871410

Phase1, Recruiting

A Study of Revumenib and Mezigdomide in People With Leukemia

for
Leukemia, Acute Leukemia, Relapse Leukemia, Refractory Leukemia,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 12+

Code: NCT07356154

Phase1, Phase2, Recruiting

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Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Charlottesville VA
Sponsor: University of Virginia

Sex: All

Age: 18+

Code: NCT07270978

Phase1, Recruiting

Olutasidenib With Azacitidine Followed by Olutasidenib Maintenance for the Treatment of IDH1-mutated Acute Myeloid Leukemia in Patients With Prior Treatment With Venetoclax Plus a Hypomethylating Agent

for
Acute Myeloid Leukemia
Location: Sacramento CA
Sponsor: University of California, Davis

Sex: All

Age: 18+

Code: NCT07304011

Phase2, Recruiting

Imetelstat Combinations in Relapsed AML

for
Relapsed Acute Myeloid Leukemia
Location: New York NY
Sponsor: Douglas Tremblay

Sex: All

Age: 18+

Code: NCT07320235

Phase1, Recruiting

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

for
Acute Myeloid Leukemia, Myelodysplastic Syndromes,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 12+

Code: NCT04024761

Phase1, Recruiting

Phase 1 Study of AUTX-703 in Relapsed/Refractory AML and MDS

for
Relapsed Acute Myeloid Leukemia (AML),
Location: Philadelphia PA, Chapel Hill NC, Columbus OH,
Sponsor: Auron Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06846606

Phase1, Recruiting

Two Step Haplo With Radiation Conditioning

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Philadephia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 18+

Code: NCT05031897

Phase2, Recruiting

A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax

for
Acute Myeloid Leukaemia (AML), Leukemia, Blood Cancer,
Location: Boston MA
Sponsor: Jacqueline Garcia, MD

Sex: All

Age: 18+

Code: NCT07148180

Phase1, Phase2, Recruiting

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

for
Acute Myeloid Leukemia (AML)
Location: Worcester MA, Hartford CT, New Haven CT, New York NY,
Sponsor: Kura Oncology, Inc.

Sex: All

Age: 18+

Code: NCT07007312

Phase3, Recruiting

Ivosidenib as Post-HSCT Maintenance for AML

for
IDH1 Mutation, Acute Myeloid Leukemia (AML),
Location: Boston MA, Columbus OH, Atlanta GA, Milwaukee WI,
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18 - 70+

Code: NCT06707493

Phase2, Recruiting

FH-WT1-E50 TCR T Cells With Azacitidine for the Treatment of Minimal Residual Disease Positive Acute Myeloid Leukemia

for
Acute Myeloid Leukemia
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT07645469

Phase1, Recruiting

Ruxolitinib With Azacitidine Maintenance for the Treatment of Patients With Acute Myeloid Leukemia Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation

for
Acute Myeloid Leukemia
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT07548983

Phase1, Recruiting

A Study of CRD3874-SI in People With Leukemia

for
Acute Myeloid Leukemia, AML, Refractory Acute Myeloid Leukemia
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT07661095

Phase1, Recruiting

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

for
Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia
Location: Scarborough ME, The Bronx NY, Albany NY,
Sponsor: Children's Oncology Group

Sex: All

Age: 1 - 25

Code: NCT07022678

Phase3, Recruiting

Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial)

for
Core Binding Factor Acute Myeloid Leukemia
Location: Boston MA, The Bronx NY, Wilkes-Barre PA, Syracuse NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 59

Code: NCT06917911

Phase2, Recruiting

L-Annamycin for Injection in Combination With Cytarabine Injection as Second Line Therapy for Remission Induction in Adult Subjects With Refractory/Relapsed AML

for
Acute Myeloid Leukaemia (AML)
Location: Providence RI, Morristown NJ, Philadelphia PA, Miami FL,
Sponsor: Moleculin Biotech, Inc.

Sex: All

Age: 18 - 70+

Code: NCT06788756

Phase2, Phase3, Recruiting