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A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

for
Solid Tumor
Location: Boston MA, New Haven CT, The Bronx NY, Montreal,
Sponsor: Genentech, Inc.

Sex: All

Age: 18+

Code: NCT06619587

Phase1, Recruiting
Featured

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

for
Hepatocellular Carcinoma, Pancreatic Ductal Adenocarcinoma,
Location: San Antonio TX
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT06084481

Phase1, Recruiting
Featured

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

for
Neoplasms
Location: New Haven CT, Toronto, Sarasota FL, Houston TX,
Sponsor: Hoffmann-La Roche

Sex: All

Age: 18+

Code: NCT06884618

Phase1, Recruiting
Active & Responsive

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

for
Cancer, PDAC - Pancreatic Ductal Adenocarcinoma,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: Alterome Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06835569

Phase1, Recruiting
Active & Responsive

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

for
Advanced Solid Tumor
Location: East Providence RI, Charleston SC, Huntersville NC,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT06750185

Phase1, Phase2, Recruiting

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Active & Responsive

FOG-001 in Locally Advanced or Metastatic Solid Tumors

for
Cancer, Colorectal Cancer, Solid Tumor,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: Parabilis Medicines, Inc.

Sex: All

Age: 18+

Code: NCT05919264

Phase1, Phase2, Recruiting
Active & Responsive

A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor, Adult, ERBB2 Altered Breast Cancer,
Location: New Haven CT, Lake Success NY, New York NY, Fairfax VA,
Sponsor: Cogent Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT07361562

Phase1, Recruiting
Active & Responsive

A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours

for
Advanced Solid Tumor
Location: Fairfax VA, Grand Rapids MI, Nashville TN, Dallas TX,
Sponsor: Ipsen

Sex: All

Age: 18+

Code: NCT06833008

Phase1, Phase2, Recruiting
Active & Responsive

PAS-004 in Patients With Advanced Solid Tumors

for
RAS Mutation, NF1 Mutation, RAF Mutation, Advanced Solid Tumors
Location: Fairfax VA, Irving TX, San Antonio TX
Sponsor: Pasithea Therapeutics Corp.

Sex: All

Age: 18+

Code: NCT06299839

Phase1, Recruiting
Active & Responsive

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors, Genital Neoplasm, Female,
Location: Boston MA, Bethesda MD, Toronto, Celebration FL,
Sponsor: Marengo Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05592626

Phase1, Phase2, Recruiting
Active & Responsive

Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

for
Advanced Solid Tumor
Location: Pittsburgh PA, Houston TX, Beverly Hills CA
Sponsor: Strand Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06249048

Phase1, Phase2, Recruiting
Active & Responsive

A Study of PHST001 in Advanced Solid Tumors

for
Advanced Solid Tumors, Ovarian Cancer, Endometrial Cancer,
Location: Boston MA, New Haven CT, Lake Success NY, New York NY,
Sponsor: Pheast Therapeutics

Sex: All

Age: 18+

Code: NCT06840886

Phase1, Recruiting
Active & Responsive

The EASE Study: Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced Cancer

for
Advanced Solid Tumor Cancer,
Location: Aurora CO, Boulder CO
Sponsor: University of Colorado, Boulder

Sex: All

Age: 18+

Code: NCT07636200

Recruiting
Active & Responsive

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

for
Advanced Solid Tumors, Metastatic Solid Tumors,
Location: Norwich CT, Fairfax VA, Nashville TN, Saint Paul MN,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT07397338

Phase1, Phase2, Recruiting
Active & Responsive

A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: New Haven CT, Philadelphia PA, Fairfax VA,
Sponsor: Ipsen

Sex: All

Age: 18+

Code: NCT07213817

Phase1, Phase2, Recruiting
Active & Responsive

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Toronto, Grand Rapids MI, Nashville TN, Houston TX,
Sponsor: Ipsen

Sex: All

Age: 18+

Code: NCT07213830

Phase1, Phase2, Recruiting
Active & Responsive

GTB-5550 in Advanced Solid Tumors

for
Tri-specific Killer Engager, Solid Tumor, Advanced Solid Tumor
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18+

Code: NCT07541573

Phase1, Recruiting
Active & Responsive

ARC101 in Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Montreal, Toronto, Grand Rapids MI, San Antonio TX,
Sponsor: Third Arc Bio

Sex: All

Age: 18+

Code: NCT06672185

Phase1, Recruiting
Active & Responsive

A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)

for
Advanced Solid Tumors
Location: Moncton, Hackensack NJ, Fairfax VA, Kingston, Toronto,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT05067283

Phase1, Recruiting
Active & Responsive

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New York NY, Hackensack NJ,
Sponsor: ModernaTX, Inc.

Sex: All

Age: 12+

Code: NCT05533697

Phase1, Phase2, Recruiting