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A Clinical Study of YL205 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: New Haven CT, Lake Mary FL, Louisville KY, Denver CO,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06459973

Phase1, Phase2, Recruiting

A Study of PARG Inhibitor FORX-428 in Patients With Advanced Solid Tumors.

for
Advanced Solid Tumors
Location: Fairfax VA, Grand Rapids MI, St Louis MO, Houston TX,
Sponsor: FoRx Therapeutics AG

Sex: All

Age: 18+

Code: NCT07356453

Phase1, Recruiting

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

for
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC),
Location: Boston MA, New Haven CT, New York NY, Baltimore MD,
Sponsor: Revolution Medicines, Inc.

Sex: All

Age: 18+

Code: NCT07349537

Phase1, Recruiting

An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors

for
Breast Cancer, Advanced Solid Tumor
Location: New Haven CT, Birmingham AL, St Louis MO, Houston TX,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT07222267

Phase1, Recruiting

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for
Advanced Solid Tumors, Ewing Sarcoma,
Location: Boston MA, New York NY, Houston TX, Duarte CA,
Sponsor: SEED Therapeutics, Inc.

Sex: All

Age: 16+

Code: NCT07197554

Phase1, Recruiting

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A Study to Investigate the Pharmacokinetics and Safety of Subcutaneous Rilvegostomig in Adult Participants With Advanced Solid Tumors Previously Treated With Standard of Care Therapy

for
Advanced Solid Tumors
Location: Fairfax VA, Huntersville NC, San Antonio TX
Sponsor: AstraZeneca

Sex: All

Age: 18+

Code: NCT07161414

Phase1, Recruiting

First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma,
Location: Boston MA, New York NY, Fairfax VA, Durham NC,
Sponsor: Plexium, Inc.

Sex: All

Age: 18+

Code: NCT07284186

Phase1, Recruiting

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

for
Advanced Solid Tumors
Location: Cleveland OH, St Louis MO, Rochester MN,
Sponsor: Jacobio Pharmaceuticals Co., Ltd.

Sex: All

Age: 18+

Code: NCT06973564

Phase1, Phase2, Recruiting

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

for
Advanced Solid Tumor
Location: Port Huron MI, Macomb MI, Detroit MI, Lapeer MI,
Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All

Age: 18+

Code: NCT07098299

Phase1, Recruiting

A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New Haven CT, New York NY, Durham NC, Cleveland OH,
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06859762

Phase1, Recruiting

First-in-Human Trial of VBC101 in Participants With Advanced Solid Tumor Malignancies

for
Participants With Advanced Solid Tumor Malignancies
Location: Fairfax VA, Grand Rapids MI, Houston TX, San Antonio TX,
Sponsor: VelaVigo Bio Inc

Sex: All

Age: 18+

Code: NCT07136779

Phase1, Phase2, Recruiting

Phase 1/2 Study of Intravenous Injection of STX-003 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

for
Advanced Solid Tumor
Location: Nashville TN, Scottsdale AZ
Sponsor: Strand Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT07751042

Phase1, Phase2, Recruiting

A Study to Evaluate ARV-6723 Alone and With Pembrolizumab in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Fairfax VA, Huntersville NC, San Antonio TX
Sponsor: Arvinas Inc.

Sex: All

Age: 18+

Code: NCT07749586

Phase1, Phase2, Recruiting

M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

for
Advanced Solid Tumor
Location: New Haven CT, New York NY, Toronto, San Antonio TX
Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All

Age: 18+

Code: NCT07166601

Phase1, Recruiting

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor, Prostate Cancer,
Location: New York NY, Philadelphia PA, Lake Mary FL,
Sponsor: MOMA Therapeutics

Sex: All

Age: 18+

Code: NCT06545942

Phase1, Recruiting

A Phase I/II Study of CS2009 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Irving TX, Los Angeles CA
Sponsor: CStone Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06741644

Phase1, Phase2, Recruiting

PQ203 in Advanced Malignant Tumors Including Triple Negative Breast Cancer

for
Triple Negative Breast Cancer (TNBC),
Location: Toronto, Houston TX, San Antonio TX,
Sponsor: ProteinQure Inc.

Sex: All

Age: 18+

Code: NCT07190469

Phase1, Recruiting

A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Boston MA, New York NY, Hackensack NJ, Buffalo NY,
Sponsor: NextCure, Inc.

Sex: All

Age: 18+

Code: NCT06792552

Phase1, Recruiting

A Study of DS5361b in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Providence RI, Fairfax VA, Sarasota FL, Irving TX,
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT07182591

Phase1, Recruiting

Study of GS-5319 Given Alone or in Combination in Adults With Solid Tumors

for
Advanced Solid Tumor
Location: Boston MA, Fairfax VA, San Antonio TX
Sponsor: Gilead Sciences

Sex: All

Age: 18+

Code: NCT07128303

Phase1, Recruiting