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5-Azacitidine Plus PD-1/PD-L1 Inhibitor With PD-1/PD-L1 Refractory Tumors

for
Solid Tumor, Locally Advanced Solid Tumor, Metastatic Tumor
Location: Iowa City IA
Sponsor: Mohammed Milhem

Sex: All

Age: 18 - 70+

Code: NCT07404332

Phase1, Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK201 in Participants With Advanced Solid Tumors

for
Advanced Cancer, Advanced Solid Tumors
Location: Orlando FL, Nashville TN, New Orleans LA, Denver CO
Sponsor: Shanghai Allink Biotherapeutics Co., Ltd.

Sex: All

Age: 18 - 70+

Code: NCT06656390

Phase1, Phase2, Recruiting

Study of FID-022 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Tampa FL, Duarte CA, Los Angeles CA
Sponsor: Fulgent Pharma LLC.

Sex: All

Age: 18+

Code: NCT06694480

Phase1, Recruiting

A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for
Advanced Solid Tumor
Location: Boston MA, Hartford CT, New Haven CT, New York NY,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT07070232

Phase1, Phase2, Recruiting

A Study of PHN-012 in Patients With Advanced Solid Tumors

for
Colon Cancer, Pancreatic Cancer, Lung Cancer (NSCLC),
Location: Boston MA, Washington D.C. DC, Fairfax VA, Durham NC,
Sponsor: Pheon Therapeutics

Sex: All

Age: 18+

Code: NCT07127874

Phase1, Recruiting

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Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

for
Advanced Solid Tumors
Location: Toronto, Huntersville NC, Galveston TX, San Antonio TX
Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All

Age: 18+

Code: NCT07360314

Phase1, Recruiting

A Study to Test the Safety and Tolerability of SBO-154 in Patients With Advanced Solid Tumors.

for
Advanced Solid Tumors
Location: New Haven CT, Hinsdale IL, Houston TX, Scottsdale AZ,
Sponsor: Sun Pharma Advanced Research Company Limited

Sex: All

Age: 18+

Code: NCT07042100

Phase1, Recruiting

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

for
Advanced Solid Tumors, MSI-H or dMMR Advanced Solid Tumors,
Location: Houston TX
Sponsor: Eikon Therapeutics

Sex: All

Age: 18+

Code: NCT07262619

Phase1, Phase2, Recruiting

A Study Evaluating OBI-902 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Houston TX, San Antonio TX, La Jolla CA
Sponsor: OBI Pharma, Inc

Sex: All

Age: 18+

Code: NCT07124117

Phase1, Phase2, Recruiting

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

for
Advanced or Metastatic KRAS-mutant Tumor in Pancreatic Adenocarcinoma,
Location: Toronto, Dallas TX, San Antonio TX
Sponsor: Auricula Biosciences Inc.

Sex: All

Age: 18+

Code: NCT07148128

Phase1, Phase2, Recruiting

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

for
Metastatic Solid Tumor, Recurrent Solid Tumor,
Location: Boston MA, New York NY, Cleveland OH, Grand Rapids MI,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06465069

Phase1, Recruiting

A Study to Evaluate the Safety and Efficacy of MK-3120 in Participants With Advanced Solid Tumors (MK-3120-002)

for
Advanced Solid Tumors, Malignant Neoplasm
Location: Hackensack NJ, Richmond VA, Miami FL, Birmingham AL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06818643

Phase1, Phase2, Recruiting

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

for
Advanced Solid Tumors, Advanced Breast Cancer
Location: Boston MA, New Haven CT, Fairfax VA, Huntersville NC,
Sponsor: Ensem Therapeutics

Sex: All

Age: 18+

Code: NCT06993844

Phase1, Phase2, Recruiting

Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor,
Location: Raleigh NC, Tampa FL, Detroit MI, St Louis MO,
Sponsor: MOMA Therapeutics

Sex: All

Age: 18+

Code: NCT06974110

Phase1, Recruiting

A Phase I Safety and Pharmacokinetic Study of Gamitrinib Administered Intravenously to Patients With Advanced Cancer

for
Lymphoma, Advanced Solid Tumor
Location: Philadelphia PA
Sponsor: Fox Chase Cancer Center

Sex: All

Age: 18+

Code: NCT04827810

Phase1, Recruiting

Study of BG-T187 Alone and in Combination With Other Therapeutic Agents in Participants With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Hackensack NJ, Fairfax VA, Madison WI, Houston TX
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06598800

Phase1, Recruiting

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

for
Advanced Solid Tumor, Advanced Breast Cancer,
Location: Boston MA, Lebanon NH, New Hyde Park NY, New York NY,
Sponsor: Bristol-Myers Squibb

Sex: All

Age: 18+

Code: NCT06997029

Phase1, Recruiting

A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Philadelphia PA, Celebration FL, Sioux Falls SD,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06803680

Phase1, Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

for
Advanced Solid Tumors, Hematologic Malignancies
Location: Canton OH, Detroit MI, Chicago IL
Sponsor: Acrotech Biopharma Inc.

Sex: All

Age: 18+

Code: NCT07036133

Phase1, Recruiting

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

for
Malignant Mesothelioma, Metastatic Malignant Solid Tumor,
Location: Philadelphia PA, Cleveland OH, Nashville TN, Denver CO,
Sponsor: InSilico Medicine Hong Kong Limited

Sex: All

Age: 18+

Code: NCT06566079

Phase1, Recruiting