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ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

for
Advanced Solid Tumor, PDAC, HNSCC
Location: Boston MA, New Haven CT, New York NY, St Louis MO,
Sponsor: Adcendo ApS

Sex: All

Age: 18+

Code: NCT06597721

Phase1, Recruiting

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

for
Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors
Location: Augusta ME, Brewer ME, Rockport ME, Belfast ME,
Sponsor: American Society of Clinical Oncology

Sex: All

Age: 12+

Code: NCT02693535

Phase2, Recruiting

AMT-116 in Patients With Advanced Solid Tumors

for
Advanced Solid Tumor
Location: Dallas TX
Sponsor: Multitude Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT05725291

Phase1, Recruiting

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158)

for
Advanced Cancer, Anal Carcinoma, Anal Cancer, Biliary Cancer,
Location: New Brunswick NJ
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT02628067

Phase2, Recruiting

A Study to Assess Safety and Efficacy of SOT201 in Patients With Advanced/Metastatic Cancer

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Houston TX
Sponsor: SOTIO Biotech AG

Sex: All

Age: 18+

Code: NCT06163391

Phase1, Recruiting

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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

for
HER2-positive Advanced Solid Tumor
Location: Boston MA, Shirley NY, Lake Success NY, New York NY,
Sponsor: DualityBio Inc.

Sex: All

Age: 18+

Code: NCT05150691

Phase1, Phase2, Recruiting

A Study of Orally Administered JBI-802, an LSD1/HDAC6 Inhibitor, in Patients With Advanced Solid Tumors

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: Cincinnati OH
Sponsor: Jubilant Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT05268666

Phase1, Phase2, Recruiting

A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents

for
Cancer, Tumor, Solid, Malignant Neoplasm, Metastatic Cancer,
Location: Fairfax VA, Irving TX, Austin TX, San Antonio TX
Sponsor: OncoResponse, Inc.

Sex: All

Age: 18+

Code: NCT06090266

Phase1, Phase2, Recruiting

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

for
Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05039632

Phase1, Phase2, Recruiting

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib (M1774) for Advanced Solid Tumors

for
Advanced Malignant Solid Neoplasm,
Location: Boston MA, Mineola NY, New York NY, Bethesda MD,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05687136

Phase1, Recruiting

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for
Advanced Malignant Solid Neoplasm,
Location: Boston MA, New Haven CT, Trumbull CT, New York NY,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06311214

Phase2, Recruiting

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial

for
Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04693468

Phase1, Recruiting

Mobile Health Application (PACT) to Improve Engagement in Advance Care Planning

for
Locally Advanced Malignant Solid Neoplasm,
Location: Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT04515810

Recruiting

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

for
Advanced Malignant Solid Neoplasm,
Location: Bethesda MD, Richmond VA, Charlottesville VA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05327010

Phase2, Recruiting

Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

for
Advanced Malignant Solid Neoplasm,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT04511039

Phase1, Recruiting

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

for
Advanced Malignant Solid Neoplasm,
Location: New Haven CT, Trumbull CT, Bethesda MD, Pittsburgh PA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05691491

Phase1, Phase2, Recruiting

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

for
Advanced Malignant Solid Neoplasm, RAS Mutation, Lung Cancer,
Location: Nashville TN, Denver CO, Los Angeles CA
Sponsor: RasCal Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04678648

Phase1, Recruiting

Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer

for
Advanced Malignant Solid Neoplasm,
Location: Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT05705492

Phase2, Recruiting

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

for
Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05111561

Phase1, Recruiting

Telephone-Based Coaching Sessions (TAC) to Improve Advance Care Planning Participation in Advanced Cancer Patients and Their Support Person

for
Advanced Malignant Solid Neoplasm,
Location: Mount Vernon WA, Everett WA, Seattle WA
Sponsor: Fred Hutchinson Cancer Center

Sex: All

Age: 18+

Code: NCT07141407

Recruiting