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BI-1910 as a Single Agent and in Combination With Pembrolizumab for the Treatment of Advanced Solid Tumors

for
Solid Tumors, Non Small Cell Lung Cancer,
Location: New Haven CT
Sponsor: BioInvent International AB

Sex: All

Age: 18+

Code: NCT06205706

Phase1, Phase2, Recruiting

ZZ06 in Adult Patients With Advanced Solid Tumor Malignancies

for
Advanced EGFR Positive Solid Tumor
Location: The Bronx NY, Fairway KS, Los Angeles CA
Sponsor: Changchun Intellicrown Pharmaceutical Co. LTD

Sex: All

Age: 18+

Code: NCT04412616

Phase1, Recruiting

A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

for
Platinum-resistant Ovarian Cancer, Testicular Cancer,
Location: Boston MA, Providence RI, New York NY, Durham NC,
Sponsor: Context Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06515613

Phase1, Recruiting

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for
Tumor Skin, Metastatic Melanoma, Melanoma, Lung Cancer,
Location: New York NY, Pittsburgh PA, Orlando FL, Louisville KY,
Sponsor: Obsidian Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06060613

Phase1, Phase2, Recruiting

A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

for
Triple Negative Locally Advanced Non-resectable Breast Cancer,
Location: Boston MA, Toronto, Columbus OH, Nashville TN,
Sponsor: Marengo Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06827613

Phase1, Phase2, Recruiting

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SMP-3124LP in Adults With Advanced Solid Tumors

for
Solid Tumor
Location: Celebration FL, Columbus OH, Nashville TN, Denver CO,
Sponsor: Sumitomo Pharma America, Inc.

Sex: All

Age: 18+

Code: NCT06526819

Phase1, Phase2, Recruiting

Study of the Safety and Efficacy of STI-6643 in Subjects With Advanced Solid Tumors

for
Solid Tumor, Relapsed Solid Neoplasm, Refractory Tumor
Location: Fairfax VA, Sioux Falls SD, Dallas TX
Sponsor: Sorrento Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04900519

Phase1, Recruiting

A Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

for
Solid Tumor
Location: Boston MA, Fairfax VA, Grand Rapids MI, San Antonio TX,
Sponsor: PAQ Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06797336

Phase1, Recruiting

A Study of HB0045 Injection in Patients With Advanced Solid Tumors

for
Solid Tumor, Adult
Location: Canton OH
Sponsor: Shanghai Huaota Biopharmaceutical Co., Ltd.

Sex: All

Age: 18+

Code: NCT06056323

Phase1, Phase2, Recruiting

A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

for
Ovarian Cancer, Solid Tumor
Location: Boston MA, New Haven CT, New York NY, Fairfax VA,
Sponsor: OnCusp Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06234423

Phase1, Recruiting

First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

for
Solid Tumors, Sarcoma
Location: Boston MA, New York NY, Nashville TN
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT06644755

Phase1, Recruiting

5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

for
Neoplasms, Solid Tumors
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT03366116

Phase1, Recruiting

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

for
Breast Cancer, Solid Tumors, Adult
Location: Boston MA, New York NY, Fairfax VA, Tampa FL,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT05768139

Phase1, Phase2, Recruiting

A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors

for
Advanced Cancer, Gastric Cancer, Breast Cancer,
Location: Winston-Salem NC, Birmingham AL, Scottsdale AZ,
Sponsor: Minneamrita Therapeutics LLC

Sex: All

Age: 18+

Code: NCT03129139

Phase1, Recruiting

CGX1321 in Subjects With Advanced Solid Tumors and CGX1321 With Pembrolizumab or Encorafenib + Cetuximab in Subjects With Advanced GI Tumors (Keynote 596)

for
Solid Tumors, GI Cancer
Location: Boston MA, Baltimore MD, Washington DC, Durham NC,
Sponsor: Curegenix Inc.

Sex: All

Age: 18+

Code: NCT02675946

Phase1, Recruiting

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

for
Solid Tumor, Adult, Metastatic Solid Tumor, Refractory Cancer,
Location: Fairfax VA, Canton OH, Detroit MI, St Louis MO
Sponsor: Sairopa B.V.

Sex: All

Age: 18+

Code: NCT05856981

Phase1, Recruiting

HF158K1 in Patients With HER-2 Expressing Advanced Solid Tumors

for
Solid Tumors, Adult
Location: Dallas TX
Sponsor: HighField Biopharmaceuticals Corporation

Sex: All

Age: 18 - 70+

Code: NCT05861895

Phase1, Recruiting

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

for
High Grade Epithelial Ovarian Cancer,
Location: Boston MA, Providence RI, Camden NJ, Doylestown PA,
Sponsor: Genmab

Sex: All

Age: 18+

Code: NCT05579366

Phase1, Phase2, Recruiting

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

for
Advanced Cancer, Metastatic Cancer
Location: Morristown NJ, Jacksonville FL, Chicago IL,
Sponsor: Qurient Co., Ltd.

Sex: All

Age: 18+

Code: NCT05394103

Phase1, Phase2, Recruiting

A Study of Sofe-M in Participants With Selected Advanced Solid Tumors

for
Ovarian Neoplasms, Endometrial Neoplasms,
Location: Mineola NY, New York NY, Columbus OH, Grand Rapids MI,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06400472

Phase1, Recruiting