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A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

for
Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung,
Location: Boston MA, Montreal, Baltimore MD, Ottawa, Toronto,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT06131840

Phase1, Recruiting

First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.

for
Solid Tumor
Location: Orlando FL, Nashville TN, Lincoln NE, San Antonio TX
Sponsor: Corbus Pharmaceuticals Inc.

Sex: All

Age: 18+

Code: NCT06603844

Phase1, Phase2, Recruiting

Trial of DFP-14927 in Advanced Solid Tumors

for
Solid Tumor, Cancer
Location: Houston TX, Los Angeles CA
Sponsor: Delta-Fly Pharma, Inc.

Sex: All

Age: 18+

Code: NCT03943004

Phase1, Recruiting

A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation

for
Malignant Neoplasm
Location: Fairfax VA, Houston TX, San Antonio TX
Sponsor: Tyligand Pharmaceuticals (Suzhou) Limited

Sex: All

Age: 18 - 70+

Code: NCT06385925

Phase1, Phase2, Recruiting

Dual BET and CBP/p300 Inhibitor in Patients With Targeted Advanced Solid Tumors and Hematological Malignancies

for
Castrate Resistant Prostate Cancer, NUT Carcinoma,
Location: Boston MA, Jacksonville FL, Rochester MN, Houston TX,
Sponsor: Epigenetix, Inc.

Sex: All

Age: 18+

Code: NCT05488548

Phase1, Recruiting

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First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

for
Triple Negative Breast Cancer, Hormone-Resistant Breast Cancer,
Location: Baltimore MD
Sponsor: A&G Pharmaceutical Inc.

Sex: All

Age: 18+

Code: NCT05627960

Phase1, Recruiting

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

for
Solid Tumor, Advanced Cancer, Metastatic Cancer,
Location: Tampa FL
Sponsor: Memgen, Inc.

Sex: All

Age: 18+

Code: NCT05076760

Phase1, Recruiting

A Study of BGC515 Capsules in Subjects With Advanced Solid Tumors

for
Mesothelioma, Epithelioid Hemangioendothelioma(EHE),
Location: Houston TX
Sponsor: BridGene Biosciences Inc.

Sex: All

Age: 18+

Code: NCT06452160

Phase1, Recruiting

First In Human Study of CX-801 in Advanced Solid Tumors

for
Solid Tumor, Adult
Location: Pittsburgh PA, Nashville TN, Fort Worth TX,
Sponsor: CytomX Therapeutics

Sex: All

Age: 18+

Code: NCT06462794

Phase1, Recruiting

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

for
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05092373

Phase1, Recruiting

Safety and Tolerability of HTI-1066 in Subjects With Advanced Solid Tumors

for
Solid Tumor, Adult
Location: Scottsdale AZ
Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Sex: All

Age: 18+

Code: NCT03398720

Phase1, Recruiting

A Study of DM002 in Patients With Advanced Solid Tumors

for
Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms,
Location: Huntersville NC, Houston TX, Oklahoma City OK,
Sponsor: Xadcera Biopharmaceutical (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT06751329

Phase1, Phase2, Recruiting

A Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Clinical Activity of Mocertatug Rezetecan for Injection in Participants With Advanced Solid Tumors (BEHOLD-1)

for
Solid Tumors, Neoplasms
Location: Boston MA, Mineola NY, New York NY, Toronto, Montreal,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT06431594

Phase1, Recruiting

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

for
Melanoma (Skin Cancer),
Location: Lake Success NY, Fairfax VA, Detroit MI, Cincinnati OH,
Sponsor: Aminex Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07287917

Phase1, Phase2, Recruiting

Phase 1 Study of PF-08046033 in Advanced Solid Tumors

for
Non-Small-Cell Lung, Esophageal Cancer, Cutaneous Melanoma
Location: New Haven CT, Trumbull CT, Fairfax VA, Nashville TN,
Sponsor: Pfizer

Sex: All

Age: 18+

Code: NCT07519655

Phase1, Recruiting

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

for
KRAS-mutant Non-small Cell Lung Cancer (NSCLC),
Location: Boston MA, Philadelphia PA, Fairfax VA, Tampa FL,
Sponsor: Kestrel Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07458347

Phase1, Recruiting

A Phase 1 Study of D3S-003 as Monotherapy in Participants With Advanced Solid Tumors With a KRAS p.G12D Mutation.

for
KRAS P.G12D
Location: New Haven CT, Houston TX, San Antonio TX
Sponsor: D3 Bio (Wuxi) Co., Ltd

Sex: All

Age: 18+

Code: NCT07456046

Phase1, Recruiting

A Study of YL201 in Combination With Other Anti-Cancer Therapies in Patients With Advanced Solid Tumors

for
Thoracic Neoplasms, Lung Diseases, Small Cell Lung Carcinoma
Location: Fairfax VA, Louisville KY, Houston TX
Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All

Age: 18+

Code: NCT07407933

Phase1, Phase2, Recruiting

A Phase 1 Study of JMT108 in Participants With Advanced Solid Tumors

for
Cancer, Cancer (Solid Tumors)
Location: Fairfax VA, Huntersville NC, Dallas TX
Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07317505

Phase1, Recruiting

A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors

for
Colorectal Cancer, Pancreatic Cancer,
Location: Boston MA, Fairfax VA, San Antonio TX,
Sponsor: PAQ Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07300150

Phase1, Recruiting